Recruiting

Nicotine & Cannabis

Sponsor:

Roswell Park Cancer Institute

Code:

NCT07167225

Conditions

Cigarette Smoking-Related Carcinoma

E-Cig Use

Eligibility Criteria

Sex: All

Age: 18 - 25

Healthy Volunteers: Accepted

Interventions

Effectiveness of different recruitment approaches

Choice of study completion locations

Cannabis Engagement Assessment

E-cigarette dependence Scale

Nicotine dependence Scale

Study Details

Brief summary:

This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and/or cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use behaviors of consumers.

Conditions

Cigarette Smoking-Related Carcinoma

E-Cig Use

Study ID

NCT07167225

Start date

Apr 3, 2025

Status verified date

Aug, 2026

Completion date

Oct 1, 2028

Anticipated

Primary completion date

Oct 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 25

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Young adult (18-25 years old).
  • Ability to read and write in English.
  • Participants must fall into one of the following groups (based on self-report):
  • Predominant e-cigarette consumer: defined as using nicotine-containing e-cigarettes daily for the past six months but not having used other nicotine containing products more than weekly or cannabis products for the past month.
  • Predominant cannabis consumer: defined as using cannabis at least 3x/week for the past six months in any form, including smoking, vaping, and oral use, with no more than weekly use of any nicotine or tobacco products.
  • E-cigarette-cannabis co-consumers: defined as daily use of nicotine e-cigarettes and use of cannabis at least 3x/week, including smoking, vaping, and oral use, for at least the past six months, with no use of other nicotine containing products more than weekly
  • Predominant cigarette consumers: defined as using cigarettes at least daily for the past six months, but not have used other nicotine-containing products more than weekly or cannabis products for the past month
  • Predominant cigarette-cannabis co-consumers: defined as those reporting daily cigarette use and use of cannabis at least 3x/week (including smoking or vaping) for at least the past six months, with no more than weekly use of other nicotine-containing products
  • No self-reported diagnosis of kidney disease (current, or within the past year prior to the study visit).
  • Participants must understand the voluntary nature of this study and sign a written informed consent form before proceeding with study activities.

Exclusion Criteria:

  • Individuals under the age of 18 or over the age of 25.
  • Currently pregnant or breastfeeding (female participants).
  • Unwilling or unable to follow protocol requirements

Study Design

Enrollment

150 participants

Anticipated

Interventions and Outcome Measures

Arms

E-cigarette consumers

Predominant e-cigarette consumers

Cannabis consumers

Predominant cannabis consumers

e-cigarette -cannabis coconsumers

Consumers who use both e-cigarettes and cannabis .

Cigarette coconsumers

Predominant cigarette consumer

Cigarette-cannabis coconsumer

Consumers who use both Cigarette and cannabis

Interventions

Effectiveness of different recruitment approaches

Subjects will asked which type of recruitment material they've seen when completing the screening survey

Choice of study completion locations

subjects will choose location when coordinator calls to schedule appointment

Cannabis Engagement Assessment

Self reported measure of current cannabis use that contains 30 questions assessing quantity, frequency of use and method of consumption in the past 30 days.

E-cigarette dependence Scale

A 22-item questionnaire measuring e-cigarette dependence. Higher scores indicate greater dependence.

Nicotine dependence Scale

Self reported measure of current nicotine use that contains 27 questions assessing quantity, frequency of use in past 6 months

Co use practices QUestionnaire

Self reported measure of nicotine and cannabis use that contains 25 questions assessing quantity, frequency and practices of use in past 30 days

Primary outcome measure

  • Differences in biomarker levels across groups [ Time Frame: 1 study session lasting 1 hour ]

Central Contacts and Locations

Central contacts

ASK RPCI

1-800-767-9355askroswell@roswellpark.org

Locations

Roswell Park Comprehensive Cancer Center

Recruiting

Buffalo, New York, United States, 14263

Contacts

ASK RPCI

877-275-7724

More Information

Sponsor

Roswell Park Cancer Institute

Last update posted

Aug 26, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Roswell Park Cancer Institute on 2026-08-26.