Recruiting

TMS, TBS

Sponsor:

Washington State University

Code:

NCT07171359

Conditions

Alcohol Use Disorder

Opioid Use Disorder

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

TMS Low-Dose

TMS High-Dose

Study Details

Brief summary:

The study aims to explore the potential of Transcranial Magnetic Stimulation (TMS), particularly Theta Burst Stimulation (TBS), as an adjunctive treatment to enhance recovery outcomes (consumption and craving; withdrawal symptoms; mental, physical, sleep, and cognitive health; engagement with therapy, etc.) in individuals with Opioid Use Disorder (OUD) and individuals with Alcohol Use Disorder (AUD). This project will be completed in partnership with Another Chance Rehab (Portland): Portland's top addiction treatment program offering evidence-based treatment programs for a range of substance use disorders. Another Chance Rehab will serve as the project site for this work.

Conditions

Alcohol Use Disorder

Opioid Use Disorder

Study ID

NCT07171359

Start date

Jun 1, 2027

Status verified date

May, 2026

Completion date

Oct 1, 2027

Anticipated

Primary completion date

Jun 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • 18+ years old
  • Enrolled in the Intensive Outpatient Program at Another Chance Drug \& Alcohol Rehab Center of Portland, Portland, OR.
  • Diagnosed with Opioid Use Disorder
  • Diagnosed with Alcohol Use Disorder

Exclusion Criteria:

  • Children <18 years old
  • Pregnant
  • Non-English speaking
  • Currently taking prescription benzodiazepines or anti-convulsive medications
  • In active alcohol or opioid withdrawal
  • History of seizure disorder diagnosis
  • History of Schizophrenia, Bipolar Disorder, Mania

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

no intervention: Treatment As Usual

Study participants in this arm will engage in intensive outpatient alcohol and addiction treatment provided as it usually is for all patients in this program.

active comparator: 3-Minute TMS

TAU + 3-minute TMS: Participants complete TAU as described above, with one 3-minute session of TMS TBS delivered each morning, prior to commencement of their regularly scheduled daily therapy activities, for 5 days/week, for a total of four-weeks (20 sessions total).

active comparator: 9-Minute TMS

TAU + 9-minute TMS: Participants complete TAU as described above, with one 9-minute session of TMS TBS delivered each morning, prior to commencement of their regularly scheduled daily therapy activities, for 5 days/week, for a total of four-weeks (20 sessions total).

Interventions

TMS Low-Dose

one 3-minute session of TMS TBS delivered each morning, prior to commencement of their regularly scheduled daily therapy activities, for 5 days/week, for a total of four-weeks (20 sessions total).

TMS High-Dose

One 9-minute session of TMS TBS delivered each morning, prior to commencement of their regularly scheduled daily therapy activities, for 5 days/week, for a total of four-weeks (20 sessions total).

Primary outcome measure

  • Engagement in Treatment As Usual activities [ Time Frame: 4 weeks ]
  • Engagement in Treatment As Usual Activities [ Time Frame: 4 weeks ]
  • Engagement in Treatment As Usual Activities [ Time Frame: 4 weeks ]
  • Engagement in Treatment As Usual Activities [ Time Frame: 4 weeks ]

Central Contacts and Locations

Central contacts

Matthew E Layton, MD, PhD

509-389-1108layton@wsu.edu

Poppy M Gardiner, PhD

509-428-4236poppymay.gardiner@wsu.edu

Locations

Another Chance Drug & Alcohol Rehab Center of Portland

Recruiting

Portland, Oregon, United States, 97232

Contacts

John Morgan, CADC II, QMHA

503-995-3718johnm@anotherchancerehab.com

Benjamin Schwartz, MD

503-997-3543bens@recoveryworksnw.com

More Information

Sponsor

Washington State University

Last update posted

May 29, 2026

Last verified

May, 2026

Keywords

  • Transcranial Magnetic Stimulation
  • Opioid Use Disorder
  • Alcohol Use Disorder
  • Intensive Outpatient Treatment
  • Theta Burst Stimulation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-02. This information was provided to ClinicalTrials.gov by Washington State University on 2026-05-29. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.