Recruiting

Smartphone Data

Sponsor:

Dartmouth-Hitchcock Medical Center

Code:

NCT07174557

Conditions

Depression

Major Depressive Disorder

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

MoodTriggers Application

Study Details

Brief summary:

Researchers hope to see if the data smartphones collect continuously can be used to predict if patient's depression symptoms will return. They will do this by collecting data from patient's smartphones and comparing it to their depression symptoms. If this method is successful, researchers could develop a smartphone application to help healthcare providers better monitor patient's depression and intervene earlier if symptoms return.

Conditions

Depression

Major Depressive Disorder

Study ID

NCT07174557

Start date

May 20, 2026

Status verified date

Aug, 2026

Completion date

Jun 30, 2028

Anticipated

Primary completion date

Apr 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adult patients (18 years or older)
  • Treated for depression within Dartmouth Health collaborative care model (CoCM) sites who are discharged from CoCM without depression (PHQ-9 < 10)
  • Have access to and ability to use a smartphone (Android version ≥ 6 or iOS version ≥ 11).

Exclusion Criteria:

  • Identified as high risk due to active suicidality, psychosis, or bipolar disorder - Discharged from CoCM with ongoing depressive symptoms (PhQ-9 > 10

Study Design

Enrollment

320 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Phase 1: Sensing System Calibration (N = 120)

We expect that participants will be in this research study for six months. Participants will be asked to download an app on their smartphone. This app will collect data from the phone's sensors. Participants will also be asked to answer some questions about their mood each month.

active comparator: Phase 2: Early warning system (n = 100)

This study is randomized which means that in order to learn about the effect of the Smartphone App, half the people in this study will use it, and the other half will not. If participants decide to enroll into this research study, they may be assigned by chance to download a Smartphone App. This App will collect data from the phone's sensors. Participants will also be asked to complete questionnaires about their mood each month.

no intervention: Phase 2: Usual Care (n = 100)

This study is randomized which means that in order to learn about the effect of the Smartphone App, half the people in this study will use it, and the other half will not. If participants decide to enroll into this research study, they may be assigned by chance to have usual care. Participants will be asked to complete questionnaires about their mood each month.

Interventions

MoodTriggers Application

The Mood Triggers application, developed by Dr. Jacobson, will be used for collecting smartphone sensor data. This HIPAA-compliant app has been incorporated into various projects at Dartmouth, Stanford, and MGH/Harvard, with development supported by NIDA, NIMHD, NCI, and the Department of Veterans Affairs. The Mood Triggers app will capture a wide range of metrics, including psychomotor agitation, sleep disturbances, low behavioral activation, social contact, exposure to natural light, heart rate, heart rate variability, and screen time. The app also tracks the patient's screen time and app usage data. The Mood Triggers App will be installed on the smartphones at time of informed consent for all 120 patients enrolled in Phase 1 and for 100 clinical trial participants randomized to the "early warning system" (intervention arm) in Phase 2. Data will be collected from the Mood Triggers App starting on day of discharge from care and for 6 months post-discharge date.

Primary outcome measure

  • Monthly depression relapse [ Time Frame: discharge, 6-months post-discharge ]

Central Contacts and Locations

Central contacts

Nicholas C Jacobson, PhD

(603) 646-7037nicholas.c.jacobson@dartmouth.edu

Locations

Dartmouth College

Recruiting

Hanover, New Hampshire, United States, 03755

Contacts

Nicholas C Jacobson, PhD

(603) 646-7037nicholas.c.jacobson@dartmouth.edu

Dartmouth-Hitchcock Clinics

Recruiting

Lebanon, New Hampshire, United States, 03766

Contacts

Nicholas C Jacobson, PhD

(603) 646-7037nicholas.c.jacobson@dartmouth.edu

More Information

Sponsor

Dartmouth-Hitchcock Medical Center

Last update posted

Aug 11, 2026

Last verified

Aug, 2026

Keywords

  • Depression
  • Smartphone monitoring
  • Risk detection
  • Collaborative care

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Dartmouth-Hitchcock Medical Center on 2026-08-11.