Recruiting

Advance Care Planning

Sponsor:

Mayo Clinic

Code:

NCT07174661

Conditions

Advanced Malignant Solid Neoplasm

Malignant Brain Neoplasm

Recurrent Advanced Malignant Solid Neoplasm

Eligibility Criteria

Sex: All

Age: 18 - 39

Healthy Volunteers: Not accepted

Interventions

Advance Care Planning

Educational Intervention

Electronic Health Record Review

Survey Administration

Study Details

Brief summary:

This clinical trial studies whether educational tools work to improve early advance care planning (ACP) in adolescents and young adults (AYAs) with solid tumors that may have spread from where they first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and high-grade brain tumors. The incidence of AYA cancers is on the rise with approximately 90,000 new diagnoses yearly in the United States. Cancer remains the leading cause of disease-related death among AYAs, which could be due to patients having more advanced disease at presentation. It is recommended that AYAs begin ACP conversations at the start of treatment. ACP includes clarifying goals of care, discussions about end-of-life preferences, and completing a legal document that states the treatment or care a person wishes to receive or not receive if they become unable to make medical decisions (advance directive). The educational tools in this study include an early ACP educational video featuring AYAs with cancer and an ACP appointment geared for AYAs. Patients can access and watch the educational video at home prior to their scheduled ACP appointment. During the ACP appointment, a tailored ACP guide made specifically for AYAs is reviewed and questions regarding ACP are answered. This may help to introduce the importance of key ACP concepts, which may improve early ACP in AYAs with advanced solid tumors and high-grade brain tumors.

Conditions

Advanced Malignant Solid Neoplasm

Malignant Brain Neoplasm

Recurrent Advanced Malignant Solid Neoplasm

Study ID

NCT07174661

Start date

Sep 2, 2025

Status verified date

Jul, 2026

Completion date

Jun 30, 2027

Anticipated

Primary completion date

Jun 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 39

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18-39 at initial cancer diagnosis

  • Patient <18 years of age are not included in this pilot as Mayo Clinic in Arizona (MCA) does not treat pediatric patients
  • Recently diagnosed (defined as 12 months or less from initial diagnosis or advance stage relapse) with either a stage III/IV solid malignancy or high-grade brain tumor. This includes patients who have stage III/IV recurrence of previously stage I/II solid malignancy
  • Actively receiving primary oncologic care at Mayo Clinic Arizona
  • Able to read, understand, and speak English
  • Those who have completed prior advanced directive documents are still eligible to participate.

Exclusion Criteria:

  • Age < 18 or > 39 at initial cancer diagnosis
  • Diagnosed with stage I/II solid malignancy, low-grade brain tumor, or hematologic malignancy
  • Not receiving primary oncologic care at Mayo Clinic Arizona
  • Unable to read, understand, and speak English
  • Patients > 12 months from initial diagnosis or advanced stage relapses, in survivorship or on hospice
  • No internet or computer/smart phone access

Study Design

Enrollment

50 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Supportive care (early ACP)

Patients watch a brief, on-demand early ACP educational video at baseline and then one month later attend an ACP appointment with either an AYA social worker or AYA palliative medicine physician assistant over 1 hour.

Interventions

Advance Care Planning

Attend ACP appointment

Educational Intervention

Watch on-demand early ACP educational video

Electronic Health Record Review

Ancillary studies

Survey Administration

Ancillary studies

Primary outcome measure

  • Feasibility of implementing routine, early Advance Care Planning (ACP) [ Time Frame: Up to 1 year ]
  • Satisfaction with each intervention component (Acceptability) [ Time Frame: Up to 1 year ]

Central Contacts and Locations

Central contacts

Sey Oloyede

507-538-6811oloyede.oluwaseyitan@mayo.edu

Clinical Trials Referral Office

855-776-0015mayocliniccancerstudies@mayo.edu

Locations

Mayo Clinic in Arizona

Recruiting

Scottsdale, Arizona, United States, 85259

Contacts

Sey Oloyede

507-538-6811oloyede.oluwaseyitan@mayo.edu

Clinical Trials Referral Office

855-776-0015mayocliniccancerstudies@mayo.edu

Principal Investigator:

Allison C. Rosenthal, DO

More Information

Sponsor

Mayo Clinic

Last update posted

Jul 8, 2026

Last verified

Jul, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-07-08.