Recruiting

MRI Comparison

Sponsor:

University of Missouri-Columbia

Code:

NCT07175077

Conditions

Small-cell Lung Cancer

Brain Metastases

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

7t MRI

Study Details

Brief summary:

Comparison of a 7t MRI to standard of care 1.5t/3t MRI scans to determine if earlier detection of brain metastases are possible on a 7t.

Conditions

Small-cell Lung Cancer

Brain Metastases

Study ID

NCT07175077

Start date

Nov 1, 2025

Status verified date

Nov, 2025

Completion date

Sep, 2027

Anticipated

Primary completion date

Sep, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patient must have a histologically confirmed diagnosis of small-cell lung cancer (SCLC). • Patient must have an MRI of the brain, performed within 4 weeks prior to consent, documenting no evidence of brain metastases or leptomeningeal disease.
  • Patient also must not have a history of brain metastases or leptomeningeal disease.
  • Patient must refuse PCI and agree to surveillance with brain MRI scans (1.5T/3T).
  • Patient must be ≥ 18 years of age.
  • Patient must have ECOG Performance Status of 0-2
  • Patients must be able to tolerate the 7T MRI

Exclusion Criteria:

  • Patient must not have a contraindication to an MRI, such as implanted metal devices or foreign bodies.
  • Patient must not have a contraindication to gadolinium contrast administration during MR imaging.
  • Patient must not have other metastatic malignancies requiring current active treatment.
  • Pregnant patients are excluded. Pregnancy status will be confirmed verbally.

Study Design

Enrollment

20 participants

Anticipated

Interventions and Outcome Measures

Interventions

7t MRI

7t brain MRI followed by up to 12 months of standard of care 1.5t/3t MRI scans

Primary outcome measure

  • 7t MRI Brain Metastases Detection [ Time Frame: 3, 6, 9, 12 months after 7T MRI ]

Central Contacts and Locations

Central contacts

Brooke McDaniel

573-884-7488mcdanielbl@health.missouri.edu

Locations

University of Missouri

Recruiting

Columbia, Missouri, United States, 65212

Contacts

Brooke McDaniel

(573) 882-7440mcdanielbl@health.missouri.edu

Principal Investigator:

Bo Lu, MD

More Information

Sponsor

University of Missouri-Columbia

Last update posted

Dec 2, 2025

Last verified

Nov, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Missouri-Columbia on 2025-12-02.