Recruiting

Observational Study

Sponsor:

Mayo Clinic

Code:

NCT07178509

Conditions

Spontaneous Coronary Artery Dissection

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Stress Echocardiography with Contrast

Study Details

Brief summary:

This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.

Conditions

Spontaneous Coronary Artery Dissection

Study ID

NCT07178509

Start date

Nov 25, 2025

Status verified date

Jan, 2026

Completion date

Sep, 2027

Anticipated

Primary completion date

Sep, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adult >18 years old
  • Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history

Exclusion Criteria:

  • Unable to give consent
  • Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine.
  • Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®.
  • Pregnant.
  • Unable to interrupt breastfeeding.
  • Within 3 months of a heart attack.
  • Severe aortic stenosis.
  • Severe, uncontrolled hypertension (>200/110 mmHg at baseline).

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Arms

Spontaneous coronary artery dissection (SCAD)

Subject has a history of spontaneous coronary artery dissection (SCAD)

Healthy Subjects

Subjects are healthy with no significant medical history

Interventions

Stress Echocardiography with Contrast

Stress Echocardiography with Contrast will be used to assess heart function and blood flow response to stressors.

Primary outcome measure

  • Change in Microvascular Function [ Time Frame: Baseline, immediately after the Stress Echocardiography ]
  • Change in Blood Pressure [ Time Frame: Baseline, immediately after the Stress Echocardiography ]
  • Change in Heart Rate [ Time Frame: Baseline, immediately after the Stress Echocardiography ]

Central Contacts and Locations

Central contacts

Pamela Engrav

507-255-6938engrav.pamela@mayo.edu

Locations

Mayo Clinic

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Pamela Engrav

507-255-6938engrav.pamela@mayo.edu

Principal Investigator:

Marysia S Tweet, M.D., M.S.

More Information

Sponsor

Mayo Clinic

Last update posted

Jan 7, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-01-07.