Sponsor:
Alnylam Pharmaceuticals
Code:
NCT07181109
Conditions
High Risk Cardiovascular Disease
Hypertension
High Cardiovascular Risk
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
Zilebesiran
Placebo
Brief summary:
Conditions
High Risk Cardiovascular Disease
Hypertension
High Cardiovascular Risk
Study ID
NCT07181109
Start date
Sep 22, 2025
Status verified date
Sep, 2026
Completion date
Sep 23, 2030
Anticipated
Primary completion date
Sep 23, 2030
Anticipated
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Enrollment
11000 participants
Anticipated
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary purpose
Treatment
Arms
experimental: Zilebesiran 300 mg
placebo comparator: Placebo
Interventions
Zilebesiran
Placebo
Primary outcome measure
Central contacts
Locations
Clinical Trial Site
Recruiting
Birmingham, Alabama, United States, 35205
Clinical Trial Site
Recruiting
Birmingham, Alabama, United States, 35211
Clinical Trial Site
Recruiting
Fairhope, Alabama, United States, 36532
Clinical Trial Site
Recruiting
Foley, Alabama, United States, 36535
Clinical Trial Site
Recruiting
Huntsville, Alabama, United States, 35801
Clinical Trial Site
Recruiting
Huntsville, Alabama, United States, 35805
Clinical Trial Site
Recruiting
Sheffield, Alabama, United States, 35660
Clinical Trial Site
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Chandler, Arizona, United States, 85224
Clinical Trial Site
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Gilbert, Arizona, United States, 85296
Clinical Trial Site
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Mesa, Arizona, United States, 85213
Clinical Trial Site
Recruiting
Phoenix, Arizona, United States, 85015
Clinical Trial Site
Recruiting
Phoenix, Arizona, United States, 85020
Clinical Trial Site
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Sun City, Arizona, United States, 85351
Clinical Trial Site
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Sun City West, Arizona, United States, 85375
Clinical Trial Site
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Tempe, Arizona, United States, 85283
Clinical Trial Site
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Tucson, Arizona, United States, 85715
Clinical Trial Site
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Tucson, Arizona, United States, 85741
Clinical Trial Site
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Yuma, Arizona, United States, 85364
Clinical Trial Site
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Little Rock, Arkansas, United States, 72204
Clinical Trial Site
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Little Rock, Arkansas, United States, 72205
Clinical Trial Site
Recruiting
Beverly Hills, California, United States, 90211
Clinical Trial Site
Recruiting
Chula Vista, California, United States, 91910
Clinical Trial Site
Recruiting
Covina, California, United States, 91723
Clinical Trial Site
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Escondido, California, United States, 92025
Clinical Trial Site
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Glendale, California, United States, 91206
Clinical Trial Site
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Huntington Beach, California, United States, 92648
Clinical Trial Site
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La Jolla, California, United States, 92037
Clinical Trial Site
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Lancaster, California, United States, 93534
Clinical Trial Site
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Long Beach, California, United States, 90815
Clinical Trial Site
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Lynwood, California, United States, 90262
Clinical Trial Site
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Newhall, California, United States, 91321
Clinical Trial Site
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Northridge, California, United States, 91325
Clinical Trial Site
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Pasadena, California, United States, 91105
Clinical Trial Site
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San Diego, California, United States, 92111
Clinical Trial Site
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San Dimas, California, United States, 91773
Clinical Trial Site
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San Ramon, California, United States, 94583
Clinical Trial Site
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Tarzana, California, United States, 91356
Clinical Trial Site
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Toluca Lake, California, United States, 91602
Clinical Trial Site
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Torrance, California, United States, 90502
Clinical Trial Site
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Tustin, California, United States, 92780
Clinical Trial Site
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Vista, California, United States, 92081
Clinical Trial Site
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Walnut Creek, California, United States, 94598
Clinical Trial Site
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Wheat Ridge, Colorado, United States, 80033
Clinical Trial Site
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Bridgeport, Connecticut, United States, 06610
Clinical Trial Site
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Boca Raton, Florida, United States, 33434
Clinical Trial Site
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Brandon, Florida, United States, 33511
Clinical Trial Site
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Fleming Island, Florida, United States, 32003
Clinical Trial Site
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Fort Lauderdale, Florida, United States, 33308
Clinical Trial Site
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Hialeah, Florida, United States, 33012
Clinical Trial Site
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Hollywood, Florida, United States, 33024
Clinical Trial Site
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Homestead, Florida, United States, 33030
Clinical Trial Site
Recruiting
Jacksonville, Florida, United States, 32205
Clinical Trial Site
Recruiting
Jacksonville, Florida, United States, 32216
Clinical Trial Site
Recruiting
Jensen Beach, Florida, United States, 34957
Clinical Trial Site
Recruiting
Leesburg, Florida, United States, 34748
Clinical Trial Site
Recruiting
Melbourne, Florida, United States, 32934
Clinical Trial Site
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Miami, Florida, United States, 33126
Clinical Trial Site
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Miami, Florida, United States, 33134
Clinical Trial Site
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Miami, Florida, United States, 33135
Clinical Trial Site
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Miami, Florida, United States, 33155
Clinical Trial Site
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Miami, Florida, United States, 33169
Clinical Trial Site
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Miami, Florida, United States, 33186
Clinical Trial Site
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Orlando, Florida, United States, 32825
Clinical Trial Site
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Palm Springs, Florida, United States, 33406
Clinical Trial Site
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Tampa, Florida, United States, 33612
Clinical Trial Site
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Tampa, Florida, United States, 33615
Clinical Trial Site
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Wellington, Florida, United States, 33449
Clinical Trial Site
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Winter Park, Florida, United States, 32789
Clinical Trial Site
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Atlanta, Georgia, United States, 30318
Clinical Trial Site
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Atlanta, Georgia, United States, 30342
Clinical Trial Site
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Brunswick, Georgia, United States, 31520
Clinical Trial Site
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Canton, Georgia, United States, 30114
Clinical Trial Site
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Columbus, Georgia, United States, 31901
Clinical Trial Site
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Columbus, Georgia, United States, 31904
Clinical Trial Site
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Conyers, Georgia, United States, 30012
Clinical Trial Site
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Conyers, Georgia, United States, 30094
Clinical Trial Site
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Fayetteville, Georgia, United States, 30214
Clinical Trial Site
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Hinesville, Georgia, United States, 31313
Clinical Trial Site
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Johns Creek, Georgia, United States, 30024
Clinical Trial Site
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Lawrenceville, Georgia, United States, 30044
Clinical Trial Site
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Macon, Georgia, United States, 31201
Clinical Trial Site
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Stonecrest, Georgia, United States, 30038
Clinical Trial Site
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Suwanee, Georgia, United States, 30024
Clinical Trial Site
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Chicago, Illinois, United States, 60640
Clinical Trial Site
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Hazel Crest, Illinois, United States, 60429
Clinical Trial Site
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Oak Brook, Illinois, United States, 60523
Clinical Trial Site
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Orland Park, Illinois, United States, 60462
Clinical Trial Site
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Peoria, Illinois, United States, 61636
Clinical Trial Site
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Springfield, Illinois, United States, 62701
Clinical Trial Site
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Tinley Park, Illinois, United States, 60477
Clinical Trial Site
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Avon, Indiana, United States, 46123
Clinical Trial Site
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Evansville, Indiana, United States, 47714
Clinical Trial Site
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Evansville, Indiana, United States, 47715
Clinical Trial Site
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Greenfield, Indiana, United States, 46140
Clinical Trial Site
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South Bend, Indiana, United States, 46617
Clinical Trial Site
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Valparaiso, Indiana, United States, 46383
Clinical Trial Site
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Hutchinson, Kansas, United States, 67502
Clinical Trial Site
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Kansas City, Kansas, United States, 66160
Clinical Trial Site
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Topeka, Kansas, United States, 66606
Clinical Trial Site
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Wichita, Kansas, United States, 67214
Clinical Trial Site
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Wichita, Kansas, United States, 67218
Clinical Trial Site
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Bowling Green, Kentucky, United States, 42101
Clinical Trial Site
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Lexington, Kentucky, United States, 40503
Clinical Trial Site
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Versailles, Kentucky, United States, 40383
Clinical Trial Site
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Hammond, Louisiana, United States, 70403
Clinical Trial Site
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Lafayette, Louisiana, United States, 70503
Clinical Trial Site
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New Orleans, Louisiana, United States, 70112
Clinical Trial Site
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Opelousas, Louisiana, United States, 70570
Clinical Trial Site
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Shreveport, Louisiana, United States, 71105
Clinical Trial Site
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Slidell, Louisiana, United States, 70458
Clinical Trial Site
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Zachary, Louisiana, United States, 70791
Clinical Trial Site
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Baltimore, Maryland, United States, 21229
Clinical Trial Site
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Beltsville, Maryland, United States, 20705
Clinical Trial Site
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Bowie, Maryland, United States, 20715
Clinical Trial Site
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Lanham, Maryland, United States, 20706
Clinical Trial Site
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Rockville, Maryland, United States, 20850
Clinical Trial Site
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Flint, Michigan, United States, 48504
Clinical Trial Site
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Lansing, Michigan, United States, 48912
Clinical Trial Site
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Petoskey, Michigan, United States, 49770
Clinical Trial Site
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Shelby, Michigan, United States, 48315
Clinical Trial Site
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Southfield, Michigan, United States, 48075
Clinical Trial Site
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Troy, Michigan, United States, 48085
Clinical Trial Site
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Troy, Michigan, United States, 48098
Clinical Trial Site
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Richfield, Minnesota, United States, 55423
Clinical Trial Site
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Saint Paul, Minnesota, United States, 55102
Clinical Trial Site
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Jackson, Mississippi, United States, 39216
Clinical Trial Site
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Olive Branch, Mississippi, United States, 38654
Clinical Trial Site
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Port Gibson, Mississippi, United States, 39150
Clinical Trial Site
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Ridgeland, Mississippi, United States, 39157
Clinical Trial Site
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Kansas City, Missouri, United States, 64108
Clinical Trial Site
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Kansas City, Missouri, United States, 64111
Clinical Trial Site
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Kansas City, Missouri, United States, 64151
Clinical Trial Site
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St Louis, Missouri, United States, 63136
Clinical Trial Site
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St Louis, Missouri, United States, 63141
Clinical Trial Site
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Fremont, Nebraska, United States, 68025
Clinical Trial Site
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Omaha, Nebraska, United States, 68114
Clinical Trial Site
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Las Vegas, Nevada, United States, 89102
Clinical Trial Site
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Las Vegas, Nevada, United States, 89107
Clinical Trial Site
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Las Vegas, Nevada, United States, 89121
Clinical Trial Site
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Las Vegas, Nevada, United States, 89148
Clinical Trial Site
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Portsmouth, New Hampshire, United States, 03801
Clinical Trial Site
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Brick, New Jersey, United States, 08724
Clinical Trial Site
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Bridgewater, New Jersey, United States, 08807
Clinical Trial Site
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Flemington, New Jersey, United States, 08822
Clinical Trial Site
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Albuquerque, New Mexico, United States, 87106
Clinical Trial Site
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New Windsor, New York, United States, 12553
Clinical Trial Site
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North Massapequa, New York, United States, 11758
Clinical Trial Site
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Riverhead, New York, United States, 11901
Clinical Trial Site
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Rosedale, New York, United States, 11422
Clinical Trial Site
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The Bronx, New York, United States, 10461
Clinical Trial Site
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West Seneca, New York, United States, 14224
Clinical Trial Site
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Westfield, New York, United States, 14787
Clinical Trial Site
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Durham, North Carolina, United States, 27704
Clinical Trial Site
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Greenville, North Carolina, United States, 27834
Clinical Trial Site
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High Point, North Carolina, United States, 27260
Clinical Trial Site
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Jacksonville, North Carolina, United States, 28546
Clinical Trial Site
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Kings Mountain, North Carolina, United States, 28086
Clinical Trial Site
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Monroe, North Carolina, United States, 28112
Clinical Trial Site
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Statesville, North Carolina, United States, 28625
Clinical Trial Site
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Fargo, North Dakota, United States, 58104
Clinical Trial Site
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Beavercreek, Ohio, United States, 45431
Clinical Trial Site
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Cincinnati, Ohio, United States, 45212
Clinical Trial Site
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Cincinnati, Ohio, United States, 45219
Clinical Trial Site
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Columbus, Ohio, United States, 31904
Clinical Trial Site
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Columbus, Ohio, United States, 43213
Clinical Trial Site
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Dayton, Ohio, United States, 45409
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Lima, Ohio, United States, 45801
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Maumee, Ohio, United States, 43537
Clinical Trial Site
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Moraine, Ohio, United States, 45439
Clinical Trial Site
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Edmond, Oklahoma, United States, 73013
Clinical Trial Site
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Moore, Oklahoma, United States, 73160
Clinical Trial Site
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Norman, Oklahoma, United States, 73069
Clinical Trial Site
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Oklahoma City, Oklahoma, United States, 73120
Clinical Trial Site
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Camp Hill, Pennsylvania, United States, 17701
Clinical Trial Site
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Horsham, Pennsylvania, United States, 19044
Clinical Trial Site
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Linwood, Pennsylvania, United States, 19061
Clinical Trial Site
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Media, Pennsylvania, United States, 19063
Clinical Trial Site
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Philadelphia, Pennsylvania, United States, 19114
Clinical Trial Site
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Uniontown, Pennsylvania, United States, 15401
Clinical Trial Site
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Columbia, South Carolina, United States, 29205
Clinical Trial Site
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Greenville, South Carolina, United States, 29607
Clinical Trial Site
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Greer, South Carolina, United States, 29650
Clinical Trial Site
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Sioux Falls, South Dakota, United States, 57104
Clinical Trial Site
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Chattanooga, Tennessee, United States, 37404
Clinical Trial Site
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Chattanooga, Tennessee, United States, 37412
Clinical Trial Site
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Knoxville, Tennessee, United States, 37909
Clinical Trial Site
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Knoxville, Tennessee, United States, 37923
Clinical Trial Site
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Allen, Texas, United States, 75013
Clinical Trial Site
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Amarillo, Texas, United States, 79106
Clinical Trial Site
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Amarillo, Texas, United States, 79124
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Arlington, Texas, United States, 76012
Clinical Trial Site
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Arlington, Texas, United States, 76015
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Austin, Texas, United States, 78735
Clinical Trial Site
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Austin, Texas, United States, 78759
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Beaumont, Texas, United States, 77702
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Carrollton, Texas, United States, 75006
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Dallas, Texas, United States, 75226
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Dallas, Texas, United States, 75235
Clinical Trial Site
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Dallas, Texas, United States, 75246
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Duncanville, Texas, United States, 75137
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El Paso, Texas, United States, 79905
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Euless, Texas, United States, 76040
Clinical Trial Site
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Houston, Texas, United States, 77002
Clinical Trial Site
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Houston, Texas, United States, 77024
Clinical Trial Site
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Houston, Texas, United States, 77025
Clinical Trial Site
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Houston, Texas, United States, 77036
Clinical Trial Site
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Houston, Texas, United States, 77043
Clinical Trial Site
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Houston, Texas, United States, 77061
Clinical Trial Site
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Houston, Texas, United States, 77070
Clinical Trial Site
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Houston, Texas, United States, 77095
Clinical Trial Site
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Houston, Texas, United States, 77429
Clinical Trial Site
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Humble, Texas, United States, 77338
Clinical Trial Site
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Katy, Texas, United States, 77450
Clinical Trial Site
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Kingwood, Texas, United States, 77339
Clinical Trial Site
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Laredo, Texas, United States, 78041
Clinical Trial Site
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McAllen, Texas, United States, 78503
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McKinney, Texas, United States, 75069
Clinical Trial Site
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McKinney, Texas, United States, 75071
Clinical Trial Site
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Mesquite, Texas, United States, 75149
Clinical Trial Site
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Missouri City, Texas, United States, 77459
Clinical Trial Site
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Paris, Texas, United States, 75462
Clinical Trial Site
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Pasadena, Texas, United States, 77504
Clinical Trial Site
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Plano, Texas, United States, 75024
Clinical Trial Site
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Port Arthur, Texas, United States, 77642
Clinical Trial Site
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San Antonio, Texas, United States, 78220
Clinical Trial Site
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San Antonio, Texas, United States, 78229
Clinical Trial Site
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San Antonio, Texas, United States, 78231
Clinical Trial Site
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San Antonio, Texas, United States, 78258
Clinical Trial Site
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Sherman, Texas, United States, 75092
Clinical Trial Site
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Sugar Land, Texas, United States, 77479
Clinical Trial Site
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Tomball, Texas, United States, 77375
Clinical Trial Site
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Waco, Texas, United States, 76712
Clinical Trial Site
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Bountiful, Utah, United States, 84010
Clinical Trial Site
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Bountiful, Utah, United States, 84025
Clinical Trial Site
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Layton, Utah, United States, 84041
Clinical Trial Site
Recruiting
Arlington, Virginia, United States, 22205
Clinical Trial Site
Recruiting
Danville, Virginia, United States, 24541
Clinical Trial Site
Recruiting
Fairfax, Virginia, United States, 22031
Clinical Trial Site
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Falls Church, Virginia, United States, 22042
Clinical Trial Site
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Manassas, Virginia, United States, 20109
Clinical Trial Site
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Newport News, Virginia, United States, 23606
Clinical Trial Site
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Norfolk, Virginia, United States, 23502
Clinical Trial Site
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Richmond, Virginia, United States, 23219
Clinical Trial Site
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Suffolk, Virginia, United States, 23435
Clinical Trial Site
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Winchester, Virginia, United States, 22601
Clinical Trial Site
Recruiting
Bellevue, Washington, United States, 98007
Clinical Trial Site
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Kenosha, Wisconsin, United States, 53144
Clinical Trial Site
Recruiting
Brampton, Canada, L6S 0C6
Clinical Trial Site
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Brampton, Canada, L6Z 4N5
Clinical Trial Site
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Burlington, Canada, L7M 1K9
Clinical Trial Site
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Chicoutimi, Canada, G7H 7K9
Clinical Trial Site
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Etobicoke, Canada, M8Z 4E4
Clinical Trial Site
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Etobicoke, Canada, M9R 4E1
Clinical Trial Site
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Greater Sudbury, Canada, P3C 1S8
Clinical Trial Site
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Laval, Canada, H7T 2P5
Clinical Trial Site
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Lévis, Canada, G6W 0M5
Clinical Trial Site
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Longueuil, Canada, J4H 4B9
Clinical Trial Site
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Mirabel, Canada, J7J 2K8
Clinical Trial Site
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Mississauga, Canada, L5K 2L3
Clinical Trial Site
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Moncton, Canada, E1C 2Z3
Clinical Trial Site
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Moncton, Canada, E1G 5C4
Clinical Trial Site
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Montreal, Canada, H1M 1B1
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Montreal, Canada, H1M 1L3
Clinical Trial Site
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Peterborough, Canada, K9J 0B2
Clinical Trial Site
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Québec, Canada, G1L 3L5
Clinical Trial Site
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Québec, Canada, G1R 2J6
Clinical Trial Site
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Québec, Canada, G1V 4G5
Clinical Trial Site
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Richmond, Canada, V6V 2X3
Clinical Trial Site
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Saint-Jérôme, Canada, J7Z 2V4
Clinical Trial Site
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Scarborough, Canada, M1B 4Z8
Clinical Trial Site
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Sherbrooke, Canada, 8193462887
Clinical Trial Site
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Sydney, Canada, B1S 0K1
Sponsor
Alnylam Pharmaceuticals
Last update posted
Sep 18, 2026
Last verified
Sep, 2026
Keywords
Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-08. This information was provided to ClinicalTrials.gov by Alnylam Pharmaceuticals on 2026-09-18. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.