Recruiting

LC-OCT

Sponsor:

Roswell Park Cancer Institute

Code:

NCT07182240

Conditions

Basal Cell Carcinoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

LC-OCT Imaging

Study Details

Brief summary:

To assess the feasibility and provide information on the utility of noninvasive line field confocal optical coherence tomography (LC-OCT) for the presurgical assessment of Mohs micrographic surgery sites in patients undergoing removal of cutaneous basal cell carcinomas (BCC).

Conditions

Basal Cell Carcinoma

Study ID

NCT07182240

Start date

Dec 22, 2025

Status verified date

May, 2026

Completion date

Jun 22, 2027

Anticipated

Primary completion date

Jun 22, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥ 18 years
  • Participant must understand the investigational nature of this study and provide written consent prior to receiving any study-related procedure.
  • Participant must be clinically eligible for Mohs surgery as determined by their referring dermatologist and the Mohs surgeon.
  • The participant must have a BCC with superficial histology or a BCC with multiple histological features that also include superficial histology, which is appropriate for Mohs surgery.

Exclusion Criteria:

  • Known or reported allergy to mineral oil, the optical agent used during imaging.
  • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
  • . Any condition which in the investigator's opinion deems the subject an unsuitable candidate to undergo imaging procedure.
  • Unwilling or unable to follow protocol requirements

Study Design

Enrollment

60 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

other: Noninvasive Imaging Procedue -Line-field optical coherence tomography(LC-OCT)

LC-OCT imaging

Interventions

LC-OCT Imaging

handheld imaging device will take high resolution images of lesion

Primary outcome measure

  • Number of cases with fully evaluable images [ Time Frame: 1.5 years ]

Central Contacts and Locations

Central contacts

Ask RPCI

1-800-767-9355askrpc@Roswellpark.org

Locations

Roswell Park Comprehensive Cancer Center

Recruiting

Buffalo, New York, United States, 14263

More Information

Sponsor

Roswell Park Cancer Institute

Last update posted

Jun 1, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Roswell Park Cancer Institute on 2026-06-01.