Recruiting

HIIT

Sponsor:

University of Virginia

Code:

NCT07182955

Conditions

MINOCA

Shortness of Breath

Atherosclerotic Heart Disease of Native Coronary Artery

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

EXERCISE TRAINING WITH OR WITHOUT MEDICATION

Study Details

Brief summary:

The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it.

This study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) have poor cardiorespiratory fitness and its effect on quality of life.

Investigators also want to see if a structured high-intensity exercise program (HIIT), done with remote monitoring, can safely improve heart function, fitness, and quality of life in these patients. The Investigators will use a special exercise test called cardiopulmonary exercise testing to look for patterns that can help explain exercise limitations and quality of life in ANOCA before and after a remote high-intensity exercise program.

Conditions

MINOCA

Shortness of Breath

Atherosclerotic Heart Disease of Native Coronary Artery

Study ID

NCT07182955

Start date

Aug 11, 2025

Status verified date

Sep, 2025

Completion date

Apr 14, 2026

Anticipated

Primary completion date

Mar 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18-85
  • ANOCA (Anginal symptoms of chest pain or exertional dyspnea suspected to be from myocardial ischemia Invasive or CT coronary angiogram without obstructive epicardial CAD (≥50% left main or ≥70% other epicardial stenosis or fractional flow reserve ≤0.80)
  • Able to use the wearable and participate in a remote exercise program
  • Able to participate in intermittent high-intensity training.
  • Able to perform cardiopulmonary exercise testing (CPET)
  • Able to provide Health-related quality of life questionnaire (HRQOL)
  • Participants must be able to understand and provide informed consent in English and complete the study questionnaire in English

Exclusion Criteria:

  • Systolic heart failure (LVEF <50% or NYHA class III symptoms)
  • Prior myocardial infarction, coronary revascularization
  • Inability to safely undergo cardiopulmonary exercise testing, based on investigator's judgment
  • Pregnancy (due to unknown effects on CPET exercise markers)
  • Inability to provide informed consent
  • Life expectancy <1 year
  • Prisoners
  • Cognitively impaired
  • Non-English speaking

Study Design

Enrollment

25 participants

Anticipated

Intervention Model

Single group

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Exercise

Remote 4 weeks of high-intensity interval exercise training on three non-consecutive days of the week.

Interventions

EXERCISE TRAINING WITH OR WITHOUT MEDICATION

Remote 4 weeks of high-intensity interval exercise training on three non-consecutive days of the week.

Primary outcome measure

  • Examine cardiorespiratory fitness (change in VO2max in mL/kg/min) with cardiopulmonary exercise testing (CPET) Phenotype. [ Time Frame: 4 weeks ]

Central Contacts and Locations

Central contacts

Rahel Askari

434-243-7195rahel.askari@uvahealth.org

Locations

University of Virginia Health System

Recruiting

Charlottesville, Virginia, United States, 22908

Contacts

Rahel Askari

434-243-7195rahel.askari@uvahealth.org

Principal Investigator:

Jamieson M Bourque, MD, MHS

More Information

Sponsor

University of Virginia

Last update posted

Sep 19, 2025

Last verified

Sep, 2025

Keywords

  • ANOCA/MINOCA
  • High Intensity Interval Training
  • CPET Phenotype
  • Cardiorespiratory Fitness

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Virginia on 2025-09-19.