Recruiting

CHX vs. EDTA

Sponsor:

University of Alabama at Birmingham

Code:

NCT07191262

Conditions

Extraction Sites After Removal and Bone Replacement Grafting at Extraction Sockets of Dentally Hopeless Single-rooted Teeth

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

0.12% CHX and Essential Oil mouthrinse

2.6% EDTA and 0.2% EDTA mouth rinse

Study Details

Brief summary:

This study will compare commercially available, commonly used mouth rinses (0.12% chlorhexidine (CHX) vs. Ethylenediaminetetraacetic acid (EDTA)) for immediate post-operative and daily antiseptic use after tooth extraction and ridge preservation grafting followed by daily use of commercially available an essential oil (EO) mouthrinse and EDTA mouthrinse.

Conditions

Extraction Sites After Removal and Bone Replacement Grafting at Extraction Sockets of Dentally Hopeless Single-rooted Teeth

Study ID

NCT07191262

Start date

Mar 2, 2026

Status verified date

Mar, 2026

Completion date

Dec, 2028

Anticipated

Primary completion date

Dec, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Able to read and provide informed consent in English
  • At least 18 years old
  • Established and registered patient of the UAB School of Dentistry
  • Patients presenting with one single rooted tooth determined to need extraction and simultaneous ridge preservation bone grafting for future dental implant placement.
  • Presence of periodontally healthy, non-carious neighboring teeth and/or healthy restored dental implants on either side of the tooth planned for extraction.
  • No anticipated need for surgical and/or endodontic care at teeth adjacent to the proposed surgical site during the study period.

Exclusion Criteria:

  • Non-English speaking
  • Age less than 18 years old or older than 85 years old
  • Smokers/nicotine users (>10 cigarettes or equivalent/day)
  • Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing
  • Multiple adjacent teeth require extraction and grafting
  • Absence of adjacent teeth/implants on either side of the tooth to be extracted.
  • Documented or suspected allergy or sensitivity to any study product

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: 0.12% CHX and Essential Oil mouthrinse

0.12% CHX and Essential Oil mouthrinse

experimental: 2.6% EDTA and 0.2% EDTA mouth rinse

2.6% EDTA and 0.2% EDTA mouth rinse

Interventions

0.12% CHX and Essential Oil mouthrinse

0.12% CHX mouthrinse will be used to rinse for 1 minute with 15 mL twice daily starting day 1 after surgery through day 14. Patients will be instructed to use OTC essential oil mouthrinse 15mL once daily until the conclusion of the study (day 15 to day 84).

2.6% EDTA and 0.2% EDTA mouth rinse

.6% EDTA mouthrinse will be used to rinse for 1 minute with 15 mL twice daily starting day 1 after surgery through day 14. Patients will be instructed to use 0.2% EDTA mouthrinse 15mL once daily until the conclusion of the study (day 15 to day 84).

Primary outcome measure

  • The wound closure after extraction and ridge preservation grafting at 2, 4, and 8, and 12-weeks. [ Time Frame: From baseline to 2 weeks, 4 weeks, 8 weeks and 12 weeks postoperatively. ]

Central Contacts and Locations

Central contacts

Maria L Geisinger, DDS, MS

205-934-4984miagdds@uab.edu

Sarah Jane Startley, DMD

205-975-8711ss1971@uab.edu

Locations

University of Alabama at Birmingham

Recruiting

Birmingham, Alabama, United States, 35294-0007

Contacts

Maria Geisinger, DDS, MS

205-934-4984miagdds@uab.edu

Sarah Startley, DMD

205-975-8711ss1971@uab.edu

Principal Investigator:

Maria Geisinger, DDS, MS

More Information

Sponsor

University of Alabama at Birmingham

Last update posted

Mar 20, 2026

Last verified

Mar, 2026

Keywords

  • Extraction sites
  • Ridge preservation grafting
  • Soft tissue healing
  • Dimensional ridge changes
  • Antimicrobial mouth rinse

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Alabama at Birmingham on 2026-03-20.