Recruiting
Phase 2

CT Imaging

Sponsor:

University of Wisconsin, Madison

Code:

NCT07192133

Conditions

CT Scan

Computed Tomography

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

CT scan

Study Details

Brief summary:

The goal of this clinical trial is to learn if a new computed tomography (CT) lung perfusion imaging method is as effective as standard of care (SOC) CT imaging. The main question it aims to answer is:

  • Does the new contrast-free method provide more information about lung perfusion than SOC?

Participants will undergo a 30 minute chest CT.

Conditions

CT Scan

Computed Tomography

Study ID

NCT07192133

Start date

Jan 26, 2026

Status verified date

Jun, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18 years or older
  • Able to sign and date the informed consent form
  • Will undergo a clinically-indicated CT exam of the head, neck, chest, abdomen, pelvis, or extremities

Exclusion Criteria:

  • Pregnant or lactating
  • In need of urgent or emergent care
  • Have any conditions that, in the opinion of the PI or designee, would interfere with the evaluation of the results or constitute a health hazard for the participant

Study Design

Enrollment

30 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: CT scan

Participants undergoing a CT

Interventions

CT scan

Dynamic contrast-free chest CT scan

Primary outcome measure

  • Lung x-ray pulsatility index (XPI) [ Time Frame: 30 minutes ]
  • Magnitude of XPI [ Time Frame: 30 minutes ]
  • Presence of XPI [ Time Frame: 30 minutes ]
  • Spatial distribution of XPI signal [ Time Frame: 30 minutes ]

Central Contacts and Locations

Central contacts

Radiology Studies

608-282-8349radstudy@uwhealth.org

Locations

University of Wisconsin - Madison

Recruiting

Madison, Wisconsin, United States, 53705

Principal Investigator:

Matthew Smith, MD, PhD

More Information

Sponsor

University of Wisconsin, Madison

Last update posted

Jun 10, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Wisconsin, Madison on 2026-06-10.