Recruiting

Blood Flow Restriction

Sponsor:

University of New Brunswick

Code:

NCT07196371

Conditions

Type 2 Diabetes

Eligibility Criteria

Sex: All

Age: 19 - 64

Healthy Volunteers: Not accepted

Interventions

Aerobic Training with Blood Flow Restriction

Standard Aerobic Training

Study Details

Brief summary:

The goal of this trial is to learn if blood flow restriction training with treadmill walking is possible for individuals living with type 2 diabetes. It will also learn about how the blood flow restriction with treadmill walking could improve health.

The main questions it aims to answer are:

Is 6 weeks of treadmill walking with blood flow restriction reasonable for people with type 2 diabetes to perform? Does treadmill walking with blood flow restriction training help manage type 2 diabetes better than just treadmill walking?

Researchers will compare treadmill walking with blood flow restriction to treadmill walking without blood flow restriction to see if blood flow restriction works to manage type 2 diabetes based on fitness and blood sugar levels.

Participants will:

Perform treadmill walking with or without blood flow restriction for 96 minutes a week for 6 weeks.

Visit the lab before and after the exercise for tests and questionnaires.

Conditions

Type 2 Diabetes

Study ID

NCT07196371

Start date

Jan 1, 2026

Status verified date

Jan, 2026

Completion date

Dec, 2028

Anticipated

Primary completion date

Dec, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 19 - 64

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosed with type 2 diabetes (5.7% < HbA1c < 9.0%)
  • Not regularly physically active (150 mins moderate-vigorous physical activity per week)

Exclusion Criteria:

  • Musculoskeletal issues preventing exercise training
  • Unstable medications over the last 3 months
  • Absolute contraindications to BFR (i.e. peripheral vascular disease)
  • A self-reported diagnosis of low iron concentrations, anemia, or being treated for these conditions
  • A diagnosis of any red blood cell-altering condition (i.e., sickle cell anemia, poikilocytosis)
  • Currently living with any cardiovascular disease, which would impact the ability to participate in exercise safely
  • Currently prescribed any medication which would impact the ability to use a heart rate monitor to accurately track intensity

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Aerobic Training with Blood Flow Restriction

Participants will perform aerobic training with blood flow restriction.

active comparator: Standard Aerobic Training

Participants will perform aerobic training.

Interventions

Aerobic Training with Blood Flow Restriction

Participants will undergo a 6-week aerobic training intervention with blood flow restriction applied to the lower limbs.

Blood flow restriction will be applied using a blood pressure cuff set between 60-80% of limb arterial occlusion pressure.

Training will consist of treadmill walking at 40-50% of heart rate reserve (HRR) for 32 minutes per session, 3 times per week for a total of 96 minutes per week.

Standard Aerobic Training

Participants will follow the same aerobic training protocol as the AT+BFR group but without blood flow restriction.

Training will consist of treadmill walking at 40-50% of HRR for 32 minutes per session, 3 times per week for a total of 96 minutes per week.

Primary outcome measure

  • Rate of Recruitment [ Time Frame: Every 4 weeks up to 2 years ]
  • Rate of Enrollment [ Time Frame: Every 4 weeks up to 2 years ]
  • Adherence to the Intervention [ Time Frame: From enrollment to the end of intervention at week 6 ]
  • Rate of Retention for Follow-Up Testing [ Time Frame: Every 6 weeks up to 2 years ]

Central Contacts and Locations

Central contacts

Martin Senechal, PhD

506-451-6889martin.senechal@unb.ca

Jamie Burr, PhD

519-824-4120burrj@uoguelph.ca

Locations

Cardiometabolic Exercise & Lifestyle Laboratory

Recruiting

Fredericton, New Brunswick, Canada, E3B5A3

Contacts

Martin Senechal, PhD

506-451-6889martin.senechal@unb.ca

Principal Investigator:

Martin Senechal, PhD

Human Performance & Health Research Laboratory

Recruiting

Guelph, Ontario, Canada

Contacts

Jamie Burr, PhD

519-824-4120burrj@uoguelph.ca

Principal Investigator:

Jamie Burr, PhD

More Information

Sponsor

University of New Brunswick

Last update posted

Jan 26, 2026

Last verified

Jan, 2026

Keywords

  • Blood flow restriction
  • aerobic exercise
  • cardiorespiratory fitness
  • glycemia
  • feasability
  • physical activity
  • diabetes
  • continuious glucose monitor

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of New Brunswick on 2026-01-26.