Recruiting

Brain Imaging

Sponsor:

Yale University

Code:

NCT07197918

Conditions

Cardiac Arrest (CA)

Hypoxic-Ischemic Brain Injury

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

portable MRI scanner

Study Details

Brief summary:

The goal of this study is to look for brain injury in patients who had a cardiac arrest, using portable brain imaging. The portable nature of this test will also allow for serial imaging so the investigators can understand how brain injury changes over days. The results of this study may allow for bedside imaging to be available at centers without specialized imaging centers and may identify markers of brain injury that help to select the patients most likely to benefit for clinical trials.

Conditions

Cardiac Arrest (CA)

Hypoxic-Ischemic Brain Injury

Study ID

NCT07197918

Start date

Dec 2, 2025

Status verified date

Jan, 2026

Completion date

Apr, 2027

Anticipated

Primary completion date

Apr, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Unresponsive immediately after ROSC from IHCA or OHCA
  • Age ≥ 18 years of age
  • Conventional MRI is clinically indicated
  • Treatment with temperature control

Exclusion Criteria:

  • MRI contraindication according to the American Heart Association guidelines
  • Inability to tolerate supine positioning for 30 minutes
  • Diffuse loss of grey-white differentiation and sulcal effacement on head computed tomography within 6 hours of ROSC

Study Design

Enrollment

60 participants

Anticipated

Interventions and Outcome Measures

Arms

Cardiac arrest with Return of Spontaneous Circulation (ROSC)

All enrolled patients will have two to three portable MRIs ( <6 hours, 6-24 hours and one within 12 (+/- 12) hours of conventional MRI) and one conventional MRI. Standard of care will occur per the clinical team and this study will not interfere with standard of care.

Interventions

portable MRI scanner

Participants will receive 2-3 portable MRI scans: <6 hours, 6-24 hours, and within 12 (+/- 12) hours of conventional MRI

Primary outcome measure

  • Cortex- DGN HIBI score [ Time Frame: up to 6 hours post cardiac arrest, up to 24 hours post cardiac arrest and within 12 (+/- 12) hours of conventional MRI ]

Central Contacts and Locations

Central contacts

Rachel Beekman, MD

516-965-4251rachel.beekman@yale.edu

Emily Gilmore, MD, MS

203-314-0555emily.gilmore@yale.edu

Locations

Yale New Haven Hospital

Recruiting

New Haven, Connecticut, United States, 05620

More Information

Sponsor

Yale University

Last update posted

Jan 27, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Yale University on 2026-01-27.