Recruiting

Observational StudyColonoscopic Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis

Sponsor:

CND Life Sciences

Code:

NCT07204652

Conditions

PARKINSON DISEASE (Disorder)

Parkinson

Parkinson's Disease and Parkinsonism

Parkinson Disease

Eligibility Criteria

Sex: All

Age: 40 - 70+

Healthy Volunteers: Not accepted

Interventions

No Intervention: Observational Cohort

Study Details

Brief summary:

The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease. The main question it aims to answer is:

Can doctors find a protein called alpha-synuclein in colon tissue samples from people with Parkinson's disease?

Currently, Parkinson's disease is diagnosed by observing symptoms like tremors and movement problems, but by then the disease has already progressed significantly. Earlier detection could help doctors start treatment sooner.

Conditions

PARKINSON DISEASE (Disorder)

Parkinson

Parkinson's Disease and Parkinsonism

Parkinson Disease

Study ID

NCT07204652

Start date

Sep 3, 2025

Status verified date

Feb, 2026

Completion date

Sep, 2029

Anticipated

Primary completion date

Sep, 2028

Anticipated

Eligibility Criteria

Sex: All

Age: 40 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

Adults 40 to 99 years of age
Patients with a confirmed clinical diagnosis of Parkinson's disease by UKPDS Brain Bank Criteria
Patients who have agreed to undergo a routine colonoscopy as part of their surveillance for colon cancer or exclusion of other gastrointestinal diseases

Exclusion Criteria:

Use of anticoagulants (Plavix 75 mg or aspirin up to 325 mg alone is allowed)
History of colon cancer
Recent gastrointestinal illness or surgical procedures
Pregnant or planning to become pregnant before the scheduled colonoscopy
Significant cognitive impairment, as determined by study investigators
Decisionally impaired adults who cannot express understanding that this study is voluntary and for research purposes

Study Design

Enrollment

20 participants

Anticipated

Interventions and Outcome Measures

Interventions

No Intervention: Observational Cohort

Primary outcome measure

Detection of phosphorylated alpha-synuclein in colon tissue samples [ Time Frame: At time of colonoscopy procedure ]

Central Contacts and Locations

Central contacts

Magda Armendariz Sullivan

503-501-8478 armendam@ohsu.edu

Locations

Oregon Health & Science University

Recruiting

Portland, Oregon, United States, 97239

Contacts

Magda Armendariz Sullivan

503-501-8478 armendam@ohsu.edu

More Information

Sponsor

CND Life Sciences

Last update posted

Feb 11, 2026

Last verified

Feb, 2026

Keywords

Parkinson
Parkinson's Disease
Parkinson disease
Parkinson Disease (Disorder)

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-09. This information was provided to ClinicalTrials.gov by CND Life Sciences on 2026-02-11. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.