Recruiting

PMT & SFA

Sponsor:

Rutgers, The State University of New Jersey

Code:

NCT07209488

Conditions

Stroke

Dyslexia, Acquired

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Phono-Motor Therapy

Semantic Feature Analysis

Study Details

Brief summary:

This study is a low-risk, early phase 1, multicenter trial to test the use of a computational (neural network) cognitive model of reading to simulate acquired dyslexia and its treatment. The aim is to determine whether there is an advantage to receiving the treatment the model predicts to be advantageous compared to the alternative treatment. All participants will receive two full rounds of treatment. A round of treatment will consist of either phonomotor treatment (PMT) or semantic feature analysis (SFA) for 60 hours, distributed over 5 days a week for 2 hours a day.

Conditions

Stroke

Dyslexia, Acquired

Study ID

NCT07209488

Start date

Dec 3, 2025

Status verified date

May, 2026

Completion date

Sep, 2026

Anticipated

Primary completion date

Sep, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Fluent in English as a first language pre-stroke by self report.
  • Normal or corrected-to-normal vision.
  • Normal or aided hearing.
  • Left hemisphere ischemic or hemorrhagic stroke (as verified by a structural brain scan).
  • Impaired reading as confirmed by significant impairment in the Basic Skills cluster of the Woodcock Reading Mastery Test - III.

Exclusion Criteria:

  • Diagnosed pre-stroke neurological disease affecting the brain other than left hemisphere stroke.
  • Severe apraxia of speech (determined by consensus judgment among speech-language pathologists).
  • History of learning disabilities such as developmental dyslexia or current self-reported major psychiatric disorders.
  • Inability to undergo, or provide a copy of, a post-stroke brain imaging scan.

Study Design

Enrollment

12 participants

Anticipated

Allocation

Non randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Model-matched

This group will receive the therapy, either phonological or semantics-based, that matches the computational model prediction for the source of their reading impairment. They will receive this for the first 60 total hours of therapy, and for the second 60 hours of therapy.

active comparator: Model-non-matched

This group will receive the therapy, either phonological or semantics-based, that does not match the computational model prediction for the source of their reading impairment. They will receive this for the first 60 total hours of therapy. For the second 60 hours, they will receive the other therapy.

Interventions

Phono-Motor Therapy

Orthographic stimuli (letters) are introduced from the beginning as each phoneme is being trained. This maintains the focus on phonology, while emphasizing its relevance to reading. PMT consists of an initial phase focused on training of individual phonemes and phoneme sequences in spoken language, followed by written language tasks. English phonemes are first trained in isolation, followed by phoneme sequences in words and pseudowords. They are trained multi-modally through emphasis on auditory, motor, tactile-kinesthetic, visual, and orthographic representations for each consonant and vowel. When sequences are introduced, focus on phonology is maintained by training on pseudowords first before real words are introduced. Participants work on identifying, repeating, parsing, blending, and manipulating phonemes that make up the pseudoword and word stimuli. To maintain focus on phonology, pictures and definitions of the stimuli are never shown or discussed.

Semantic Feature Analysis

SFA activates semantic features of the target word to help retrieve the spoken form of the word. To target reading, a modified SFA is used with written words rather than pictures as the primary materials. Pictures are instead included for each word as a semantic feature. Stimuli will consist of 80 highly imageable nouns with a range of word frequencies. During treatment the therapist will present a written noun and ask the participant a series of questions about the features of that noun. For example, if the presented noun is "juice", the therapist would have the participant select the corresponding picture from an array of pictures. The therapist then would ask, "what do you do with it?" (eliciting a feature from the "function" category) and "where do you store it in your home?" (eliciting a feature from the "context" category). This is done for a total of 6 categories of semantic features. The process is repeated until the participant reads the noun correctly three times in a row.

Primary outcome measure

  • Woodcock Reading Mastery Test - III [ Time Frame: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy. ]
  • Test words and pseudowords [ Time Frame: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy. ]

Central Contacts and Locations

Locations

Florida State University

Recruiting

Tallahassee, Florida, United States, 32306

Contacts

Elizabeth B Madden, PhD

850-644-4088ebmadden@fsu.edu

Johns Hopkins University School of Medicine

Recruiting

Baltimore, Maryland, United States, 21287

Contacts

Argye B Hillis, MD

443-287-4610argye@jhmi.edu

Kessler Foundation

Recruiting

West Orange, New Jersey, United States, 07052

Contacts

More Information

Sponsor

Rutgers, The State University of New Jersey

Last update posted

May 6, 2026

Last verified

May, 2026

Keywords

  • reading
  • computational model
  • treatment
  • therapy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Rutgers, The State University of New Jersey on 2026-05-06.