Recruiting

Suflave vs. Golytely

Sponsor:

Morehouse School of Medicine

Code:

NCT07215000

Conditions

Colorectal Cancer Screening

Bowel Cleansing for Colonoscopy

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Golytely

Sulfave

Sutab

Study Details

Brief summary:

The purpose of this research is to compare patient preferences for two bowel preparation options: low-volume tablets (Suflave/Sutab) versus the standard colon preparation using Golytely (polyethylene glycol). The study aims to enroll approximately 300 patients, who will be randomly assigned to one of the two preparation methods in a 2:1 ratio prior to their scheduled colonoscopy appointments. Surveys will be conducted both before and after the procedures.

This project will be conducted over a 12-month period and seeks to compare patient experience of both preparation methods in an outpatient setting. The study will evaluate the rate of preparation completion, patient satisfaction, tolerance of the solutions, and the endoscopic adequacy of each method.

Eligible participants are patients aged 18 or older with upcoming colonoscopy appointments who can provide informed consent in English or Spanish. There is no health risks associated with this study, as both bowel preparation methods are FDA-approved and commonly used in clinical practice.

Conditions

Colorectal Cancer Screening

Bowel Cleansing for Colonoscopy

Study ID

NCT07215000

Start date

Oct 1, 2025

Status verified date

Oct, 2025

Completion date

Jun, 2027

Anticipated

Primary completion date

Jan, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adults over age of 18 years undergoing outpatient colonoscopy for various indications, ability to consent in English or Spanish. Patients will still be allowed to join if there is a history of colorectal cancer or previous surgery

Exclusion Criteria:

  • Patient is less than 18 years of age, any pregnant or nursing women, unable to consent, or patient is incarcerated.

Study Design

Enrollment

300 participants

Anticipated

Allocation

Randomized

Intervention Model

Single group

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

active comparator: Golytely

GoLYTELY is a prescription medicine used by adults to clean the colon before a colonoscopy or barium enema X-ray examination. GoLYTELY cleans your colon by causing you to have diarrhea (loose stools). Cleaning your colon helps your healthcare provider see the inside of your colon more clearly during your colonoscopy. Drink reconstituted solution at a rate of 8 ounces every 10 minutes, until 4 liters are consumed, or rectal effluent is clear.

other: Sulfave

Suflave is a combination, osmotic prescription laxative that may be used to cleanse the bowel in preparation for colonoscopy in adults. Suflave contains polyethylene glycol 3350, sodium sulfate, potassium chloride, magnesium sulfate, and sodium chloride, and is supplied as a powder that is mixed with a low volume of water before consuming. It tastes like a lemon-lime sports drink. Drink 8 ounces of the solution every 15 minutes until the bottle is empty, and then drink an additional 16 ounces of water during the evening. One dose of Suflave is equal to one bottle plus one flavor-enhancing packet.

other: Sutab

SUTAB comes in a kit that contains two medication bottles and a cup for water. Each bottle contains 12 tablets (pills). You'll take 12 pills (one bottle) with water from the cup the night before your exam. Later that evening, drink two more cups of water. Fill the cup to the line each time. Then, six hours before your exam, repeat all three of those steps.

Interventions

Golytely

large volume liquid prep.

Sulfave

SUFLAVE is a split-dose (2-day) regimen. A total of 2 bottles are required for complete preparation for colonoscopy. You will take 2 bottles of liquid in two separate doses. One dose of SUFLAVE is equal to one bottle plus one flavor enhancing packet.

Sutab

SUTAB comes in a kit that contains two medication bottles and a cup for water. Each bottle contains 12 tablets (pills). You'll take 12 pills (one bottle) with water from the cup the night before your exam. Later that evening, drink two more cups of water. Fill the cup to the line each time. Then, six hours before your exam, repeat all three of those steps.

Primary outcome measure

  • Patient Experience [ Time Frame: Until the end of the study ]
  • Edoscopic Adequacy [ Time Frame: Until the end of the study ]

Central Contacts and Locations

Central contacts

Julia J Liu, MD, MSc

(404) 756-1369jjliu@msm.edu

Tasha Rhymes, M.S. Ed.

(404) 756-1369trhymes@msm.edu

Locations

Morehouse School of Medicine

Recruiting

Atlanta, Georgia, United States, 30310

Contacts

Jesus Luevano, M.D.

404-971-9018jluevanojr@msm.edu

Julia Liu, M.D.

404-756-1389jjliu@msm.edu

Principal Investigator:

Jesus Luevano Jr., M.D.

More Information

Sponsor

Morehouse School of Medicine

Last update posted

Oct 9, 2025

Last verified

Oct, 2025

Keywords

  • Colorectal cancer screening
  • Bowel cleansing for colonoscopy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Morehouse School of Medicine on 2025-10-09.