Recruiting

Observational Study

Sponsor:

Rutgers, The State University of New Jersey

Code:

NCT07217522

Conditions

Pulmonary Hypertension

Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)

Pulmonary Arterial Hypertension Associated With Connective Tissue Disease

Pulmonary Arterial Hypertension Associated With Connective Tissue Disease (Disorder)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Saliva sample

Health surveys

Study Details

Brief summary:

The goal of this observational study is to learn more about how genes impact the risk of pulmonary hypertension. Anyone 18 or older living in the US is eligible, and a diagnosis of PH is NOT required. Study participation is online, and it takes about 20 minutes to complete health surveys and request a saliva collection kit sent through US mail. In return, study participants may opt to receive information about their genetic ancestry at no cost.

Conditions

Pulmonary Hypertension

Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)

Pulmonary Arterial Hypertension Associated With Connective Tissue Disease

Pulmonary Arterial Hypertension Associated With Connective Tissue Disease (Disorder)

Study ID

NCT07217522

Start date

Aug 23, 2025

Status verified date

Oct, 2025

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • age 18 years or older
  • currently living in the United States
  • able to understand and follow written instructions in English
  • have access to the internet and a computer, laptop, tablet or smart phone
  • willing to provide written informed consent for participation
  • willing to provide DNA via a saliva sample using a collection kit mailed to the study participant's home
  • willing to complete a survey with questions about health related to the study of pulmonary hypertension.

Exclusion Criteria:

  • Age 17 or below
  • Not currently living in the United States
  • Not able to participate in an online research study in English

Study Design

Enrollment

10000 participants

Anticipated

Interventions and Outcome Measures

Arms

Pulmonary hypertension cases

Study participants who have been diagnosed with any form of pulmonary hypertension, either currently or in the past.

Pulmonary hypertension controls

Study participants who have not been diagnosed with any form of pulmonary hypertension, either currently or in the past.

Interventions

Saliva sample

Saliva sample is sent via prepaid US Mail for DNA extraction

Health surveys

Health surveys are filled out online in the study portal.

Primary outcome measure

  • Genetic risk variants associated with pulmonary hypertension [ Time Frame: 2 years ]

Central Contacts and Locations

Central contacts

Tara Matise, Ph.D.

848-445-3125rugcc-ph@rutgers.edu

Steve Buyske, Ph.D.

rugcc-ph@rutgers.edu

Locations

Rutgers University, Piscataway, New Jersey 08854

Recruiting

Piscataway, New Jersey, United States, 08854

Contacts

Tara Matise, Ph.D.

848-445-3125rugcc-ph@rutgers.edu

Principal Investigator:

Tara Matise, Ph.D.

More Information

Sponsor

Rutgers, The State University of New Jersey

Last update posted

Nov 3, 2025

Last verified

Oct, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-25. This information was provided to ClinicalTrials.gov by Rutgers, The State University of New Jersey on 2025-11-03. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.