Recruiting

Neurofeedback Training

Sponsor:

Wayne State University

Code:

NCT07217925

Conditions

Well-Being, Psychological

Mood Disturbance

Emotional Regulation

Dissociation

Post Traumatic Stress Symptoms

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Neuroptimal (Zengar, Inc.) Neurofeedback

Study Details

Brief summary:

The proposed study will collect novel data evaluating the feasibility of a neurofeedback training program delivered to prospective clients with a history of clinically concerning trauma-related mental health symptoms who are on a wait list to receive obsessive compulsive disorder-specific psychotherapy at an outpatient mental health clinic. This study will evaluate the influence of neurofeedback training on participant's overall sense of well-being, and additionally, whether any enhanced well-being is subsequently associated with positive changes in symptoms of obsessive compulsive disorder, post-traumatic stress, dissociation and other trauma-related mental health symptoms, emotional regulation, etc.

Conditions

Well-Being, Psychological

Mood Disturbance

Emotional Regulation

Dissociation

Post Traumatic Stress Symptoms

Study ID

NCT07217925

Start date

Nov 1, 2025

Status verified date

Aug, 2026

Completion date

Jan, 2029

Anticipated

Primary completion date

Jun, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. being a client placed on the clinic waitlist to receive exposure-response prevention for OCD symptoms at the Anxiety and OCD Treatment Center of Ann Arbor, in Ann Arbor, MI.
2. having self-reported symptoms of OCD;
3. having post-traumatic stress symptoms as indicated by a score of 3 or higher on the Primary Care PTSD Screen for DSM-5 (PC-PTSD-5) screening measure;
4. being age 18+.
5. being a citizen of the United States of America -

Exclusion Criteria:

1. a lifetime history of significant untreated mental illness (not currently treated schizophrenia, schizoaffective disorder, bipolar disorder, or substance use disorder) or neurological or pervasive developmental disorder;
2. a documented history of epilepsy;
3. lifetime history of any head injury with loss of consciousness;
4. current exposure domestic or intimate partner violence or otherwise state that their current living conditions are unsafe;
5. current experiences of psychosis or suicidality within the last six months;
6. currently taking, or in the past month has taken benzodiazepines, narcotic drugs, or cannabis;
7. currently pregnant
8. engagement in self-harming behaviors in the last 3 months that required medical attention;
9. lack of competence to understand or consent to the study procedures;
10. lack of fluency in written and spoken English. -

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Other

Interventions and Outcome Measures

Arms

other: Neurofeedback Training

Participants in the Neurofeedback Training group will complete per-training, post-training, and post-training follow-up self-report surveys assessing overall well-being, symptoms of obsessive compulsive disorder, post-traumatic stress, OCD, dissociation and other trauma-related mental health symptoms, emotional regulation, etc. Participants in this group will all be on a wait list to receive obsessive compulsive disorder-specific psychotherapy at a local outpatient therapy clinic that specializes in the treatment of anxiety and obsessive compulsive disorders. All participants will demonstrate clinically significant post-traumatic stress symptoms and have a self-reported diagnosis of obsessive compulsive disorder.

Interventions

Neuroptimal (Zengar, Inc.) Neurofeedback

Participants in the Neurofeedback Training group will complete a total of 8 training sessions (1-2 sessions a week, each session lasting approximately 34 minutes) within a 3 month time span, using the Neuroptimal (Zengar, Inc.) neurofeedback device.

Primary outcome measure

  • Post-Traumatic Stress Disorder Checklist for the Diagnostic and Statistical Manual of Mental Disorders, Fith Edition (PTSD Checklist for DSM-5 - Standard). [ Time Frame: The measure will be administered three intervals: 1) per-training, at the beginning of the study, 2) post-training, between 2-3 months later, following the completion of the training phase, 3) as a follow-up, 3 months after the post-training interval. ]
  • Dissociative Symptoms Scale (DSS) [ Time Frame: The measure will be administered three intervals: 1) per-training, at the beginning of the study, 2) post-training, between 2-3 months later, following the completion of the training phase, 3) as a follow-up, 3 months after the post-training interval. ]
  • Yale-Brown Obsessive Compulsive Scale (Y-BOCS; with Checklist) [ Time Frame: The measure will be administered three intervals: 1) per-training, at the beginning of the study, 2) post-training, between 2-3 months later, following the completion of the training phase, 3) as a follow-up, 3 months after the post-training interval. ]
  • Difficulties in Emotion Regulation Scale (DERS) [ Time Frame: The measure will be administered three intervals: 1) per-training, at the beginning of the study, 2) post-training, between 2-3 months later, following the completion of the training phase, 3) as a follow-up, 3 months after the post-training interval. ]
  • The World Health Organization-Five Well-Being Index (WHO-5) [ Time Frame: The measure will be administered three intervals: 1) per-training, at the beginning of the study, 2) post-training, between 2-3 months later, following the completion of the training phase, 3) as a follow-up, 3 months after the post-training interval. ]
  • Patient Health Questionnaire - 8 (PHQ-8) [ Time Frame: The measure will be administered three intervals: 1) per-training, at the beginning of the study, 2) post-training, between 2-3 months later, following the completion of the training phase, 3) as a follow-up, 3 months after the post-training interval. ]
  • GAD-7 [ Time Frame: The measure will be administered three intervals: 1) per-training, at the beginning of the study, 2) post-training, between 2-3 months later, following the completion of the training phase, 3) as a follow-up, 3 months after the post-training interval. ]
  • Everyday Discrimination Scale [ Time Frame: The measure will be administered three intervals: 1) per-training, at the beginning of the study, 2) post-training, between 2-3 months later, following the completion of the training phase, 3) as a follow-up, 3 months after the post-training interval. ]

Central Contacts and Locations

Central contacts

Lisa S Panisch, PhD

3135774409hj1429@wayne.edu

Locations

Wayne State University

Recruiting

Detroit, Michigan, United States, 48202

Principal Investigator:

Lisa s Panisch, PhD

More Information

Sponsor

Wayne State University

Last update posted

Aug 19, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Wayne State University on 2026-08-19.