Recruiting

Motivational Interviewing, CBT4CBT, Financial Incentives

Sponsor:

Medical University of South Carolina

Code:

NCT07218471

Conditions

Cannabis Use Disorder

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

CBT4CBT (Computerized Cognitive Behavioral Therapy)

Motivational Interviewing

Contingency Management

Study Details

Brief summary:

This study evaluates the effects of cannabis use reduction among adults diagnosed with cannabis use disorder (CUD). Participants will undergo an 8-week intervention combining motivational interviewing, computerized cognitive behavioral therapy (CBT4CBT), and financial incentives for reduction in urinary cannabinoids. The study aims to assess improvements in cannabis-related problems, sleep, cognitive performance, CUD severity, and quality of life.

Conditions

Cannabis Use Disorder

Study ID

NCT07218471

Start date

Mar 13, 2026

Status verified date

Oct, 2025

Completion date

Jan 30, 2030

Anticipated

Primary completion date

Sep 15, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18+
  • Urinary cannabinoid level ≥ 50 ng/mL
  • DSM-5 diagnosis of CUD (mild, moderate, or severe)
  • Willingness to attempt cannabis reduction
  • Completion of Intake Visit

Exclusion Criteria:

  • Serious medical/psychiatric conditions
  • Pregnancy or breastfeeding
  • Use of cannabis in past 30 days was for medical purposes only
  • Discontinuation or reduction of cannabis use may exacerbate a pre-existing condition
  • Cognitive or understanding difficulties, as evidenced by inability to pass informed consent quiz

Study Design

Enrollment

176 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Interventions

CBT4CBT (Computerized Cognitive Behavioral Therapy)

Participants will receive one therapist-led motivational interviewing/goal setting session followed by 7 sessions of computerized CBT4CBT.

Motivational Interviewing

Participants will receive one therapist-led motivational interviewing/goal setting session followed by 7 sessions of computerized CBT4CBT.

Contingency Management

Patients will receive contingent reinforcers (financial incentives for reduction in urinary cannabinoids).

Primary outcome measure

  • Cannabis-Related Problems [ Time Frame: Week 8 (end-of-treatment) ]

Central Contacts and Locations

Central contacts

Rachel Tomko, PhD

(843) 792-5447tomko@musc.edu

Erin McClure, PhD

(843) 792-7192mccluree@musc.edu

Locations

Medical University of South Carolina

Recruiting

Charleston, South Carolina, United States, 29425

Contacts

Kevin Branson, MA, ADC, MAC

843-792-0493bransonk@musc.edu

Rachel Tomko, PhD

843-792-5447tomko@musc.edu

More Information

Sponsor

Medical University of South Carolina

Last update posted

Mar 19, 2026

Last verified

Oct, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Medical University of South Carolina on 2026-03-19.