Recruiting

Magnetocardiography

Sponsor:

Mayo Clinic

Code:

NCT07218705

Conditions

Amyloidosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

SandboxAQ CardiAQ Magnetocardiography

Study Details

Brief summary:

The primary objective of this observational study is to evaluate the utility of magnetocardiography (MCG) in diagnosing and monitoring disease progression in patients with amyloidosis, and to assess its effectiveness in comparison to other modalities, such as ECG.

Conditions

Amyloidosis

Study ID

NCT07218705

Start date

Dec 3, 2025

Status verified date

Dec, 2025

Completion date

Nov, 2027

Anticipated

Primary completion date

Nov, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria

1. Age ≥ 18 years on the date of consent
2. Ability for participant to comply with study requirements
3. Written informed consent

Exclusion Criteria

1. Pregnant or breastfeeding
2. Having an active atrial fibrillation episode as seen on most current 12-lead ECG
3. Active thoracic metal implants (including pacemaker, insertable cardiac monitor, or internal defibrillator).
4. External electrical pads or devices (e.g. Pacer pads, ECG electrodes, heart rate patch), that must remain on patient's chest during MCG scan
5. Inability to lie down in a supine/inclined position and stay still on the examination bed
6. Clinical conditions that in the opinion of the Investigator would compromise the safety of the patient or ability to complete the protocol

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Arms

Patients with amyloidosis

Interventions

SandboxAQ CardiAQ Magnetocardiography

Magnetocardiography is a non-invasive, radiation-free imaging technique that detects the magnetic field generated by the electrical activity of the heart.

Primary outcome measure

  • Receiver Operating Characteristic (ROC) curve [ Time Frame: Baseline, 6 Months, 12 Months, 18 Months ]
  • Area Under the Curve (AUC) Magnetocardiography [ Time Frame: Baseline, 6 Months, 12 Months, 18 Months ]
  • Area Under the Curve (AUC) Electrocardiogram [ Time Frame: Baseline, 6 Months, 12 Months, 18 Months ]

Central Contacts and Locations

Central contacts

Andy Dang

507-255-7752dang.phong@mayo.edu

Locations

Mayo Clinic in Rochester

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Structural Heart Research Team

(507) 255-6133konwinski.craig@mayo.edu

Principal Investigator:

Mohamad Adnan Alkhouli, MD

More Information

Sponsor

Mayo Clinic

Last update posted

Dec 22, 2025

Last verified

Dec, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2025-12-22.