Recruiting

Probiotic Supplementation

Sponsor:

University of Minnesota

Code:

NCT07219498

Conditions

Exercise Induced Muscle Damage

Delayed Onset Muscle Soreness (DOMS)

Eligibility Criteria

Sex: All

Age: 18 - 30

Healthy Volunteers: Accepted

Interventions

Lactobacillus casei

Placebo Capsule(s)

Study Details

Brief summary:

The purpose of this study is to evaluate how probiotic supplementation (PS) influences post-exercise recovery in healthy, physically active young adults. Researchers aim to determine if the Lactobacillus casei probiotic strain reduces symptoms of delayed onset muscle soreness (DOMS) based on perceived muscle soreness, pressure pain threshold, and power output following exercise induced muscle damage (EIMD).

Conditions

Exercise Induced Muscle Damage

Delayed Onset Muscle Soreness (DOMS)

Study ID

NCT07219498

Start date

Feb 5, 2026

Status verified date

Apr, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 30

Healthy Volunteers: Accepted

Inclusion Criteria:

  • complete a minimum of 150 minutes a week of at least moderate intensity exercise in either an endurance-based or resistance-based training style based on a self-reported physical activity over the past month
  • good general health with no injuries or health conditions that would affect physical activity
  • willing to abstain from consistent NSAID use and other probiotic supplements over the course of this study

Exclusion Criteria:

  • known musculoskeletal injuries or physical limitations that could interfere with performing the designated physical activity required
  • underlying conditions that could place them at an increased risk during exercise such as cardiovascular, respiratory, or metabolic diseases
  • currently take a probiotic supplement, are prescribed and taking an antibiotic during the intervention, or report using NSAIDs or steroids within the recovery time window
  • report using an NSAID more than twice a week on a regular basis

Study Design

Enrollment

24 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

active comparator: Probiotic Group

placebo comparator: Placebo Group

Interventions

Lactobacillus casei

Probiohealth is the manufacturer of this strain and they use a stringent quality control program that utilizes a multi point product variability check system.

Placebo Capsule(s)

The brand name of placebo capsules that will be used in this study is Magic Bullet Placebo Capsules. This placebo is manufactured by Progressive Placebo as stated on the product label.

Primary outcome measure

  • Change in perceived muscle soreness [ Time Frame: From baseline to post 5-week intervention ]
  • Change in pressure pain threshold (PPT) [ Time Frame: From baseline to post 5-week intervention ]
  • Change in countermovement jump assessment (CMJ) performance recovery [ Time Frame: From baseline to post 5-week intervention ]

Central Contacts and Locations

Central contacts

Jakob Fischer

507-236-8051fisc0887@d.umn.edu

Locations

University of Minnesota

Recruiting

Minneapolis, Minnesota, United States, 55455

Contacts

Jakob Fischer

507-236-8051fisc0887@d.umn.edu

More Information

Sponsor

University of Minnesota

Last update posted

May 4, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Minnesota on 2026-05-04.