Recruiting

Telerehabilitation

Sponsor:

Maya Henry

Code:

NCT07219680

Conditions

Primary Progressive Aphasia(PPA)

Semantic Dementia

Logopenic Progressive Aphasia (LPA)

Nonfluent Aphasia, Progressive

Progressive Aphasia

Eligibility Criteria

Sex: All

Age: 40+

Healthy Volunteers: Not accepted

Interventions

Multicomponent Lexical Retrieval Cascade Training

Multicomponent Video Implemented Script Training in Aphasia

Study Details

Brief summary:

The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and their primary communication partners. The study will enroll participants who speak English and/or Spanish.

The main questions the study aims to answer are:

  • Is the telerehabilitation program feasible and acceptable for people with PPA and their study partners?
  • Do participants with PPA and study partners find treatment beneficial?
  • What patterns of treatment response are seen in participants?
  • Which outcome measures are most useful for evaluating changes in communication and quality of life?

Researchers will compare participants who receive intervention immediately to participants assigned to a waitlist control group (who will receive treatment after a delay) to see whether participation in the treatment program is associated with improvements in communication and quality of life.

Participants will:

  • Take part in speech language therapy sessions delivered by video visit that combine restorative, compensatory, and partner-focused communication strategies. Treatment may take place after a waiting period.
  • Receive education and communication training together with their partner.
  • Complete speech, language, and cognitive assessments.
  • Complete questionnaires about communication abilities, daily functioning, and quality of life.

Conditions

Primary Progressive Aphasia(PPA)

Semantic Dementia

Logopenic Progressive Aphasia (LPA)

Nonfluent Aphasia, Progressive

Progressive Aphasia

Study ID

NCT07219680

Start date

Apr 1, 2026

Status verified date

Apr, 2026

Completion date

Aug, 2027

Anticipated

Primary completion date

Aug, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 40+

Healthy Volunteers: Not accepted

Inclusion Criteria for Persons with PPA:

  • A PPA (Gorno-Tempini et al., 2011) or "PPA-plus" (Mesulam et al., 2001) diagnosis
  • MMSE score of 15 or higher and must be able to produce single monosyllabic words intelligibly
  • Must speak English, Spanish or both languages (i.e., bilingual speakers of English or Spanish)
  • Hearing and vision adequate for participation in teleconference meetings
  • Must have a study partner available (someone who will commit to attending teleconference sessions, as needed, during assessment and treatment phases)

Inclusion criteria for Care Partners:

  • Partners must express willingness to attend and participate in assessment and treatment sessions, including those targeting dyadic communication goals
  • Partners must speak English, Spanish or both languages (i.e., bilingual speakers of English or Spanish)
  • Partner's hearing and vision should be adequate for participation in teleconference meetings

The participant and/or study partner must have basic experience using a computer.

Exclusion criteria for persons with PPA:

  • Other central nervous system or medical diagnosis that can account for symptoms
  • Psychiatric diagnosis that can account for symptoms

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

other: Waitlist Control

Individuals in the waitlist-control group will undergo initial assessment followed by a waiting interval of 12 (Multi-VISTA) or 13 (Multi-LRCT) weeks. Following the waiting period, they will again complete baseline assessments prior to the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment).

experimental: Immediate Treatment

Individuals in the immediate treatment group will undergo initial assessment followed immediately by the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment).

Interventions

Multicomponent Lexical Retrieval Cascade Training

In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant targets in multiple communication modalities. Biweekly (45-90 minute) sessions with a clinician target multimodal communication and the use of strategies to support word retrieval. These skills are also trained via daily independent practice. The participant meets six times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.

Multicomponent Video Implemented Script Training in Aphasia

In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Treatment focuses on production of individually-tailored, personally relevant scripts. The participant completes 30 minutes per day of independent practice, during which they speak in unison with a video model. Biweekly (45-90 minute) sessions with a clinician target clear and accurate script production, memorization, and conversational usage, as well as multimodal communication. The participant meets six times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.

Primary outcome measure

  • Change in spoken naming of trained/untrained items [ Time Frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment ]
  • Change in script production accuracy [ Time Frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment ]
  • Change in barriers and facilitators in dyad conversation [ Time Frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment ]
  • Communication Modality Inventory [ Time Frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment ]

Central Contacts and Locations

Central contacts

Henry Lab Research Coordinator

512-471-3420aphasialab@austin.utexas.edu

Grasso Lab Research Coordinator

512-232-1440multilingual.aphasia@austin.utexas.edu

Locations

University of Texas

Recruiting

Austin, Texas, United States, 78712

Contacts

Carly M Millanski, MS

512-471-3420aphasialab@austin.utexas.edu

Camille Wagner Rodriguez, MS

wagner.camille@austin.utexas.edu

Principal Investigator:

Maya L Henry, PhD

More Information

Sponsor

Maya Henry

Last update posted

Apr 21, 2026

Last verified

Apr, 2026

Keywords

  • speech-language pathology
  • neurodegenerative disease
  • logopenic
  • nonfluent
  • semantic
  • script training
  • teletherapy
  • remote
  • multimodal communication training
  • partner training
  • augmentative and alternative communication
  • AAC
  • Communication Book
  • bilingual
  • Spanish
  • Hispanic
  • Latino

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Maya Henry on 2026-04-21.