Recruiting

LIFU

Sponsor:

University of Minnesota

Code:

NCT07220655

Conditions

Healthy Participants

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Low-Intensity Focused Ultrasound (FUS or LIFU)

Study Details

Brief summary:

Our primary goal is to investigate the role of Low-Intensity Focused Ultrasound (LIFU) neuromodulation on deep brain targets, and its potential to improve cognition

Conditions

Healthy Participants

Study ID

NCT07220655

Start date

Jun 1, 2024

Status verified date

Jun, 2026

Completion date

Jul 1, 2028

Anticipated

Primary completion date

Jul 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 18 years of age or older
  • Speak English (as assessed by their ability to read/answer survey questions)
  • May be required to score in the appropriate range on self-report measures

Exclusion Criteria:

  • They have a neurological disorder which may impact their fMRI scan or cause their reaction to LIFU to differ from that of healthy adults.
  • They take any psychoactive medication.
  • They are unable to undergo fMRI scanning due to a contraindication such as claustrophobia, unremovable piercings, pregnancy, the presence of medical devices such as pacemakers, or a movement or sleep disorder.
  • Are pregnant, or may have reason to believe that they are pregnant.
  • They have a diagnosis of a psychiatric condition other than depression or anxiety

Study Design

Enrollment

100 participants

Anticipated

Intervention Model

Single group

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Low-Intensity Focused Ultrasound

Interventions

Low-Intensity Focused Ultrasound (FUS or LIFU)

We will use an established, currently-marketed device to deliver LIFU neuromodulation.

Primary outcome measure

  • Deep Brain Targets Reached [ Time Frame: Hour 1 ]
  • Multi-Source Interference Test (MSIT) Performance [ Time Frame: Hour 1 ]
  • 28/Posit Science Performance [ Time Frame: Hour 1 ]

Central Contacts and Locations

Central contacts

Miriam Freedman

tel:612-625-3330bronsteinlab@umn.edu

Locations

University of Minnesota

Recruiting

Minneapolis, Minnesota, United States, 55455

Contacts

Miriam Freedman

612-625-3330bronsteinlab@umn.edu

More Information

Sponsor

University of Minnesota

Last update posted

Jun 15, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Minnesota on 2026-06-15.