Sponsor:
GlaxoSmithKline
Code:
NCT07221227
Conditions
Non-alcoholic Fatty Liver Disease
Eligibility Criteria
Sex: All
Age: 18 - 70+
Healthy Volunteers: Not accepted
Interventions
Efimosfermin alfa
Efimosfermin alfa
Placebo
Brief summary:
Conditions
Non-alcoholic Fatty Liver Disease
Study ID
NCT07221227
Start date
Oct 24, 2025
Status verified date
Jul, 2026
Completion date
Dec 12, 2031
Anticipated
Primary completion date
Mar 29, 2028
Anticipated
Eligibility Criteria
Sex: All
Age: 18 - 70+
Healthy Volunteers: Not accepted
Enrollment
1200 participants
Anticipated
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary purpose
Treatment
Arms
experimental: Participants receiving dose level 1 of efimosfermin alfa
experimental: Participants receiving dose level 2 of efimosfermin alfa
placebo comparator: Participants receiving Placebo
Interventions
Efimosfermin alfa
Efimosfermin alfa
Placebo
Primary outcome measure
Central contacts
Locations
GSK Investigational Site
Recruiting
Chandler, Arizona, United States, 85224
Contacts
Principal Investigator:
Anita Kohli
GSK Investigational Site
Recruiting
Tucson, Arizona, United States, 85712
Contacts
Principal Investigator:
Hani Rizk
GSK Investigational Site
Recruiting
Little Rock, Arkansas, United States, 72211
Contacts
Principal Investigator:
John Baber
GSK Investigational Site
Recruiting
Arcadia, California, United States, 91006
Contacts
Principal Investigator:
Elias Tarakji
GSK Investigational Site
Recruiting
Covina, California, United States, 91723
Contacts
Principal Investigator:
Masoud Azizad
GSK Investigational Site
Recruiting
Folsom, California, United States, 95630
Contacts
Principal Investigator:
Nazir Rahim
GSK Investigational Site
Recruiting
Los Angeles, California, United States, 90057
Contacts
Principal Investigator:
Joseph Lamb
GSK Investigational Site
Recruiting
Montclair, California, United States, 91763
Contacts
Principal Investigator:
Rizwana Mohseni
GSK Investigational Site
Recruiting
Riverdale, California, United States, 30274
Contacts
Principal Investigator:
Deon Miller
GSK Investigational Site
Recruiting
San Diego, California, United States, 92120
Contacts
Principal Investigator:
Julie Doan Trang Vu
GSK Investigational Site
Recruiting
Santa Maria, California, United States, 93458
Contacts
Principal Investigator:
Keval Shah
GSK Investigational Site
Recruiting
Van Nuys, California, United States, 91405
Contacts
Principal Investigator:
Robert Jenders
GSK Investigational Site
Recruiting
Colorado Springs, Colorado, United States, 80907
Contacts
Principal Investigator:
Bhaktasharan Patel
GSK Investigational Site
Recruiting
Boynton Beach, Florida, United States, 33435
Contacts
Principal Investigator:
Aaron Cohen
GSK Investigational Site
Recruiting
Cape Coral, Florida, United States, 33914
Contacts
Principal Investigator:
Paige Kreegel
GSK Investigational Site
Recruiting
Clermont, Florida, United States, 34711
Contacts
Principal Investigator:
Edriss Estime
GSK Investigational Site
Recruiting
Fort Myers, Florida, United States, 33912
Contacts
Principal Investigator:
Charles Smith
GSK Investigational Site
Recruiting
Hialeah, Florida, United States, 33016
Contacts
Principal Investigator:
Isaac Bassan
GSK Investigational Site
Recruiting
Hialeah, Florida, United States, 33016
Contacts
Principal Investigator:
Jorge Diaz
GSK Investigational Site
Recruiting
Homestead, Florida, United States, 33033
Contacts
Principal Investigator:
Gilberto Seco
GSK Investigational Site
Recruiting
Inverness, Florida, United States, 34452
Contacts
Principal Investigator:
Paul Hellstern Jr.
GSK Investigational Site
Recruiting
Jacksonville, Florida, United States, 32216
Contacts
Principal Investigator:
Jeffry Jacqmein
GSK Investigational Site
Recruiting
Kissimmee, Florida, United States, 34744
Contacts
Principal Investigator:
Luis Alvarado Lopez
GSK Investigational Site
Recruiting
Lakeland, Florida, United States, 33803
Contacts
Principal Investigator:
James Andersen
GSK Investigational Site
Recruiting
Maitland, Florida, United States, 32751
Contacts
Principal Investigator:
Eva Maria Heurich
GSK Investigational Site
Recruiting
Miami, Florida, United States, 33135
Contacts
Principal Investigator:
Yaneicy Gonzalez Rojas
GSK Investigational Site
Recruiting
Miami, Florida, United States, 33144
Contacts
Principal Investigator:
Carlos Ramos
GSK Investigational Site
Recruiting
Miami, Florida, United States, 33155
Contacts
Principal Investigator:
Jorge Amaya
GSK Investigational Site
Recruiting
Miami, Florida, United States, 33156
Contacts
Principal Investigator:
Lazaro M Garcia
GSK Investigational Site
Recruiting
Miami, Florida, United States, 33173
Contacts
Principal Investigator:
Barbara Moscoso
GSK Investigational Site
Recruiting
Miami, Florida, United States, 33176
Contacts
Principal Investigator:
Miguel Rodriguez
GSK Investigational Site
Recruiting
Miami, Florida, United States, 33184
Contacts
Principal Investigator:
Franciso Bautista
GSK Investigational Site
Recruiting
Miami Lakes, Florida, United States, 33014
Contacts
Principal Investigator:
Miguel Aponte
GSK Investigational Site
Recruiting
Ocala, Florida, United States, 34471
Contacts
Principal Investigator:
Robert Barish
GSK Investigational Site
Recruiting
Palmetto Bay, Florida, United States, 33157
Contacts
Principal Investigator:
Karen Figueredo Reyes
GSK Investigational Site
Recruiting
Sarasota, Florida, United States, 34201
Contacts
Principal Investigator:
Guy Neff
GSK Investigational Site
Recruiting
Marietta, Georgia, United States, 30060
Contacts
Principal Investigator:
Aasim Sheikh
GSK Investigational Site
Recruiting
Topeka, Kansas, United States, 66606
Contacts
Principal Investigator:
Shekhar Challa
GSK Investigational Site
Recruiting
Bastrop, Louisiana, United States, 71220
Contacts
Principal Investigator:
Bal Raj Bhandari
GSK Investigational Site
Recruiting
Marrero, Louisiana, United States, 70072
Contacts
Principal Investigator:
Gary Reiss
GSK Investigational Site
Recruiting
Kansas City, Missouri, United States, 64131
Contacts
Principal Investigator:
Paresh Patel
GSK Investigational Site
Recruiting
Springfield, Missouri, United States, 62703
Contacts
Principal Investigator:
Dmitry Shuster
GSK Investigational Site
Recruiting
St Louis, Missouri, United States, 63141
Contacts
Principal Investigator:
Fred Williams
GSK Investigational Site
Recruiting
Las Vegas, Nevada, United States, 89106
Contacts
Principal Investigator:
Elliot Shin
GSK Investigational Site
Recruiting
East Syracuse, New York, United States, 13057
Contacts
Principal Investigator:
Barbara Connor
GSK Investigational Site
Recruiting
New York, New York, United States, 10036
Contacts
Principal Investigator:
Samar Hameed
GSK Investigational Site
Recruiting
New York, New York, United States, 10036
Contacts
Principal Investigator:
Eli Shalenberg
GSK Investigational Site
Recruiting
Fayetteville, North Carolina, United States, 28304
Contacts
Principal Investigator:
John Poulos
GSK Investigational Site
Recruiting
Morehead City, North Carolina, United States, 28557
Contacts
Principal Investigator:
Kathryn Lucas
GSK Investigational Site
Recruiting
Akron, Ohio, United States, 44320
Contacts
Principal Investigator:
Ganesh Veerappan
GSK Investigational Site
Recruiting
Springboro, Ohio, United States, 45066
Contacts
Principal Investigator:
Anjali Morey
GSK Investigational Site
Recruiting
Westlake, Ohio, United States, 44145
Contacts
Principal Investigator:
Naim Alkhouri
GSK Investigational Site
Recruiting
Chattanooga, Tennessee, United States, 37421
Contacts
Principal Investigator:
Chirag Patel
GSK Investigational Site
Recruiting
Arlington, Texas, United States, 76012
Contacts
Principal Investigator:
Reem Ghalib
GSK Investigational Site
Recruiting
Austin, Texas, United States, 78704
Contacts
Principal Investigator:
Nomita Kim
GSK Investigational Site
Recruiting
Austin, Texas, United States, 78757
Contacts
Principal Investigator:
Rohit Puskoor
GSK Investigational Site
Recruiting
Austin, Texas, United States, 78759
Contacts
Principal Investigator:
Michael Patrick Zimmerman
GSK Investigational Site
Recruiting
Bellaire, Texas, United States, 77401
Contacts
Principal Investigator:
Everald Manning
GSK Investigational Site
Recruiting
Brownsville, Texas, United States, 78526
Contacts
Principal Investigator:
Christopher Romero
GSK Investigational Site
Recruiting
Dallas, Texas, United States, 75243
Contacts
Principal Investigator:
Valentine Ebuh
GSK Investigational Site
Recruiting
DeSoto, Texas, United States, 75115
Contacts
Principal Investigator:
Haresh Boghara
GSK Investigational Site
Recruiting
Houston, Texas, United States, 77004
Contacts
Principal Investigator:
Joseph Galati
GSK Investigational Site
Recruiting
Irving, Texas, United States, 75061
Contacts
Principal Investigator:
Heather Myers
GSK Investigational Site
Recruiting
Richmond, Texas, United States, 77406
Contacts
Principal Investigator:
Brian Chou
GSK Investigational Site
Recruiting
San Antonio, Texas, United States, 78209
Contacts
Principal Investigator:
Robert Morin Jr
GSK Investigational Site
Recruiting
San Antonio, Texas, United States, 78215
Contacts
Principal Investigator:
Eric Lawitz
GSK Investigational Site
Recruiting
San Antonio, Texas, United States, 78229
Contacts
Principal Investigator:
Emanuel DeNoia
GSK Investigational Site
Recruiting
Seabrook, Texas, United States, 77586
Contacts
Principal Investigator:
Joe Pouzar
GSK Investigational Site
Recruiting
Sugar Land, Texas, United States, 77479
Contacts
Principal Investigator:
Harish Thakkar
GSK Investigational Site
Recruiting
Tomball, Texas, United States, 77375
Contacts
Principal Investigator:
Muhammad Irfan
GSK Investigational Site
Recruiting
Waco, Texas, United States, 76710
Contacts
Principal Investigator:
Gregg Lucksinger
GSK Investigational Site
Recruiting
Waco, Texas, United States, 76712
Contacts
Principal Investigator:
Hanumantha Ancha
GSK Investigational Site
Recruiting
West Jordan, Utah, United States, 84088
Contacts
Principal Investigator:
Barbara Rizzardi
GSK Investigational Site
Recruiting
Manassas, Virginia, United States, 20110
Contacts
Principal Investigator:
Nabil Andrawis
GSK Investigational Site
Recruiting
Norfolk, Virginia, United States, 23502
Contacts
Principal Investigator:
John Smith
GSK Investigational Site
Recruiting
Seattle, Washington, United States, 98105
Contacts
Principal Investigator:
Kris Kowdley
GSK Investigational Site
Recruiting
Québec, Quebec, Canada, G1N 4V3
Contacts
Principal Investigator:
Pascale Chouinard
Sponsor
GlaxoSmithKline
Last update posted
Jul 27, 2026
Last verified
Jul, 2026
Keywords
Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by GlaxoSmithKline on 2026-07-27.