Recruiting

Virtual Reality

Sponsor:

Mayo Clinic

Code:

NCT07221409

Conditions

Adjustment Disorder

Anxiety Disorder

Depression

Hematopoietic and Lymphoid System Neoplasm

Malignant Solid Neoplasm

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Questionnaire Administration

Virtual Reality (VR) Intervention

Study Details

Brief summary:

This clinical trial tests the safety, tolerability, and effectiveness of a virtual reality intervention to improve psychological symptom burden for cancer patients undergoing treatment. Virtual reality (VR) is a technology that allows users to experience and interact with three-dimensional, computer-generated environments that simulate the real world or imagined settings. The VR intervention consists of a preloaded with immersive environments designed to engage the senses through simulated sights and sounds. This may include a walk through of a serene forest, exploring vibrant coral reefs, swimming with dolphins, or standing at the base of a majestic waterfall. These environments are created to provide a relaxing and engaging experience. Completing the VR intervention may be a safe and effective way to improve quality of life, reduce anxiety, enhance focus, and promote healthy living for cancer patients undergoing treatment.

Conditions

Adjustment Disorder

Anxiety Disorder

Depression

Hematopoietic and Lymphoid System Neoplasm

Malignant Solid Neoplasm

Study ID

NCT07221409

Start date

Oct 8, 2025

Status verified date

Mar, 2026

Completion date

Oct 8, 2027

Anticipated

Primary completion date

Oct 8, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • History of cancer
  • Age between 18 to 90 years
  • Undergoing in-patient chemotherapy, bone marrow transplant (BMT), chimeric antigen receptor (CAR)-t, \& out-patient chemotherapy

Exclusion Criteria:

  • History of bipolar disorder, major depression, bipolar disorder, anxiety disorder, post traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), psychotic disorder, schizophrenia, personality disorder, substance use disorder other than caffeine or tobacco. History of suicidal ideation or attempt
  • History of treatment resistant depression, psychiatric hospitalization, syncope, transient ischemic attack (TIA), stroke, epilepsy, electroconvulsive therapy, benign positional vertigo, Meniere's disease

Study Design

Enrollment

24 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Virtual Reality (VR) Headset Intervention

Participants will undergo a single VR session to assess feasibility, tolerability, and changes in anxiety, depression, and fatigue.

Interventions

Questionnaire Administration

Participants will complete pre- and post-intervention questionnaires to assess symptoms of anxiety, depression, and fatigue.

Virtual Reality (VR) Intervention

Participants will engage in a single-session immersive Virtual Reality (VR) experience lasting approximately 20-30 minutes. The VR content will include calming, guided experiences such as nature scenes, meditation, or breathing exercises designed to promote relaxation and reduce psychological distress. The intervention will be administered in a clinical setting.

Primary outcome measure

  • Successfully complete the virtual reality (VR) intervention (Feasibility) [ Time Frame: Baseline ]
  • Absence of major issues during administration (Feasibility) [ Time Frame: Baseline ]
  • Acceptability [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

Wendi Lehman

904-953-8742lehman.wendi@mayo.edu

Telly Coney

904-953-3725coney.telleso@mayo.edu

Locations

Mayo Clinic in Florida

Recruiting

Jacksonville, Florida, United States, 32224-9980

Contacts

Wendi Lehman

904-953-8742lehman.wendi@mayo.edu

Telly Coney

904-953-3725coney.telleso@mayo.edu

Principal Investigator:

Juan C. Cardenas Rosales, MD

More Information

Sponsor

Mayo Clinic

Last update posted

Apr 2, 2026

Last verified

Mar, 2026

Keywords

  • Virtual Reality Therapy
  • VR Therapy
  • Non-Pharmacologic Intervention
  • Cancer Supportive Care

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-04-02.