Recruiting

Observational Study

Sponsor:

UCLA

Code:

NCT07222618

Conditions

Multiple Sclerosis

Multiple Sclerosis (MS) - Relapsing-remitting

Multiple Sclerosis (MS) Primary Progressive

MS (Multiple Sclerosis)

MS

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The goal of this observational study is to validate a novel, cost-effective method for real-world assessment using patient-acquired "selfie" videos in people with multiple sclerosis. The investigators aim to prove the feasibility and validity of monitoring walking changes remotely through a truly patient-centered, low-burden, low-cost approach. The main question this study aims to answer is: do remotely collected walking and speech videos from a mobile phone match the information investigators can gather from an in person visit?

Participants will collect 5 "selfie" videos at baseline, 3 months, 6 months and 12 months (about 15 minutes every 3 months). They will also come in person at baseline, 6 months, and 12 months for in person data collection (about 1 hour per in person visit).

Conditions

Multiple Sclerosis

Multiple Sclerosis (MS) - Relapsing-remitting

Multiple Sclerosis (MS) Primary Progressive

MS (Multiple Sclerosis)

MS

Study ID

NCT07222618

Start date

Oct 1, 2025

Status verified date

Oct, 2025

Completion date

Oct 1, 2028

Anticipated

Primary completion date

Oct 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Any patient with MS who is above the age of 18 yrs. Participants who are unable to consent for themselves must have a surrogate decision maker or LAR.
  • Age > 18 yrs, EDSS - <6.5, own a video recording device (smartphone, tablet, camera etc).

Exclusion Criteria:

  • Patient unwilling to participate in the study. Participants unable to consent for themselves who do not have a surrogate decision maker or LAR.

Study Design

Enrollment

300 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Validate key metrics derived from video "selfies" against the MS Functional Composite (MSFC) [ Time Frame: 1 year ]

Central Contacts and Locations

Central contacts

Kyra Henderson, Study Coordinator

415-353-8053kyra.henderson@ucsf.edu

Locations

University of California, San Francisco

Recruiting

San Francisco, California, United States, 94158

Contacts

Kyra Henderson, Study Coordinator

415-353-8053kyra.henderson@ucsf.edu

Principal Investigator:

Riley Bove, MD

More Information

Sponsor

University of California, San Francisco

Last update posted

Oct 31, 2025

Last verified

Oct, 2025

Keywords

  • multiple sclerosis
  • MS
  • digital tool
  • UCSF

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2025-10-31.