Recruiting
Phase 3

Blood Pressure Medicines

Sponsor:

Women and Infants Hospital of Rhode Island

Code:

NCT07222852

Conditions

Preeclampsia

Hypertensive Disorder of Pregnancy

Hypertension

Gestational Hypertension

Gestational Hypertension After Childbirth

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Enalapril

Standard treatment

Study Details

Brief summary:

The purpose of this study is to learn if postpartum women are willing to be randomized to different blood pressure medicines after delivery and how that affects blood pressure in women with hypertensive disorders of pregnancy.

Conditions

Preeclampsia

Hypertensive Disorder of Pregnancy

Hypertension

Gestational Hypertension

Gestational Hypertension After Childbirth

Study ID

NCT07222852

Start date

Jan 1, 2026

Status verified date

Apr, 2026

Completion date

Oct 15, 2027

Anticipated

Primary completion date

Oct 15, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Postpartum individuals
  • ≥18 years old
  • Hypertensive disorder of pregnancy
  • Enrolled in Women and Infants Hospital Hypertension Equity remote monitoring program.

Exclusion Criteria:

  • Maternal cardiac disease
  • Individuals with pre-pregnancy hypertension or diabetes
  • Allergy or contraindication to enalapril

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Enalapril

First-line anti-hypertensive treatment with enalapril

active comparator: Standard treatment

First-line anti-hypertensive treatment with standard of care treatment

Interventions

Enalapril

First-line anti-hypertensive treatment with enalapril

Standard treatment

First-line anti-hypertensive treatment per standard of care

Primary outcome measure

  • Feasibility of enrollment [ Time Frame: 4 months ]
  • Feasibility of retention [ Time Frame: 4 months ]

Central Contacts and Locations

Central contacts

Alisse Hauspurg, MD

401-274-1122ahauspurg@carene.org

Crystal Ware, RN

cware@wihri.org

Locations

Women and Infants Hospital

Recruiting

Providence, Rhode Island, United States, 02906

Contacts

Alisse Hauspurg, MD, MS

401-274-1122ahauspurg@carene.org

More Information

Sponsor

Women and Infants Hospital of Rhode Island

Last update posted

Aug 6, 2026

Last verified

Apr, 2026

Keywords

  • postpartum hypertension, preeclampsia, gestational hypertension

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Women and Infants Hospital of Rhode Island on 2026-08-06.