Recruiting
Phase 2

Observational Study

Sponsor:

Monell Chemical Senses Center

Code:

NCT07222891

Conditions

Olfactory Dysfunction

Wellbeing

Eligibility Criteria

Sex: All

Age: 7+

Healthy Volunteers: Accepted

Interventions

Patient-centered information and education

Study Details

Brief summary:

Smell dysfunction is frequent yet neglected. The sense of smell plays a crucial role in signaling disease, safety, and overall quality of life. However, the significance of a functional sense of smell in terms of health and well-being is often overlooked until one experiences a loss of smell due to injury or disease. Research demonstrates that individuals are often not self-aware of their smell dysfunction (i.e. they do not spontaneously report smell dysfunction as a symptom), especially if the changes are gradual, as in normal aging. Patients with smell dysfunction experience a marked reduction in quality of life, poor mental health, nutritional health, and brain health as well as increased 5- and 10-year mortality in older adults. This study explores whether or not enabling healthcare providers to offer resources and guidance on coping strategies for smell dysfunction improves health and wellbeing in those who experience it.

Conditions

Olfactory Dysfunction

Wellbeing

Study ID

NCT07222891

Start date

May 29, 2026

Status verified date

Oct, 2026

Completion date

Nov 30, 2027

Anticipated

Primary completion date

Sep 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 7+

Healthy Volunteers: Accepted

Inclusion Criteria:

\- Can read and understand English and have access to a reliable internet connection and a smart device or computer for the duration of the experimental sessions, unless they are part of community events in which smart devices are provided

Exclusion Criteria:

\- Known intolerance or allergy to any of the odor stimuli used

Study Design

Enrollment

1000 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Smell dysfunction detection and educational intervention

Participants will take smell tests and receive educational materials on smell dysfunction.

no intervention: Normosmia

No intervention

Interventions

Patient-centered information and education

Participants with smell dysfunction will receive patient-centered information and education about i) community engagement with individuals with smell loss, ii) available counseling and iii) medical support.

Primary outcome measure

  • Measuring depression symptoms using the PHQ-9 score [ Time Frame: PHQ-9 is completed at baseline, during 1 month follow-up session, and during the 6 month follow-up. ]

Central Contacts and Locations

Central contacts

Locations

Monell Chemical Senses Center

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Principal Investigator:

Valentina Parma

More Information

Sponsor

Monell Chemical Senses Center

Last update posted

Oct 6, 2026

Last verified

Oct, 2026

Keywords

  • Olfactory testing
  • Smell dysfunction
  • Psychological health
  • Randomized clinical trial
  • Patient-centered care
  • Access to care

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-07. This information was provided to ClinicalTrials.gov by Monell Chemical Senses Center on 2026-10-06. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.