Recruiting

Skin Cancer Prevention

Sponsor:

H. Lee Moffitt Cancer Center and Research Institute

Code:

NCT07222995

Conditions

Skin Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Precision Prevention Booklet

Standard Prevention Booklet

Study Details

Brief summary:

The purpose of this study is to examine how different messages about risk of skin cancer can impact the uptake of skin cancer prevention activities.

Conditions

Skin Cancer

Study ID

NCT07222995

Start date

Oct 10, 2025

Status verified date

Feb, 2026

Completion date

Oct 10, 2030

Anticipated

Primary completion date

Oct 10, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Be a patient of any race or ethnicity attending one of the six Tampa Family Health Centers.
  • Be 18 years of age or older.
  • Self-report skin cancer risk behaviors within the past 12 months, including: Intentional sun exposure (e.g., outdoor or indoor tanning) or unintentional sun exposure leading to sunburn.
  • Be willing to complete a baseline questionnaire and provide a saliva sample for MC1R genotyping.
  • Be able to provide informed consent (written or electronic).
  • Prefer English or Spanish for communication and study materials.

Exclusion Criteria:

  • Do not report any skin cancer risk behaviors (i.e., no tanning or sunburning in the past 12 months).
  • Are unwilling or unable to complete the baseline assessment or return the saliva kit.
  • Decline to provide informed consent.
  • Are under 18 years of age.

Study Design

Enrollment

2900 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

active comparator: Precision Prevention Intervention

Participants receive personalized skin cancer prevention materials based on MC1R genetic risk.

active comparator: Standard Prevention

Participants receive standard skin cancer prevention materials.

no intervention: Non-Intervention

Participants who do not return saliva kits will not receive intervention materials but will complete follow-up assessments.

Interventions

Precision Prevention Booklet

Precision prevention booklet anchored in their MC1R risk that incorporates gold-standard risk communication strategies, including visual risk representations and simple language.

Standard Prevention Booklet

Standard materials are similar in content to the precision prevention booklet but without any reference to MC1R risk.

Primary outcome measure

  • Change in Tanning Score [ Time Frame: Baseline, 6 months, 12 months ]
  • Number of Sunburns [ Time Frame: Baseline, 6 months, 12 months ]
  • Skin self-examination (SSE) [ Time Frame: Baseline, 6 months, 12 months ]
  • Physician-patient communication about skin cancer prevention. [ Time Frame: Baseline, 6 months, 12 months ]

Central Contacts and Locations

Central contacts

Rania Abdulla

813-745-6813Rania.Abdulla@moffitt.org

Locations

Moffitt Cancer Center

Recruiting

Tampa, Florida, United States, 33612

Principal Investigator:

Peter Kanetsky, PhD, MPH

More Information

Sponsor

H. Lee Moffitt Cancer Center and Research Institute

Last update posted

Feb 5, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by H. Lee Moffitt Cancer Center and Research Institute on 2026-02-05.