Recruiting

Isometric Handgrip Training

Sponsor:

Florida State University

Code:

NCT07223645

Conditions

Inactivity/Low Levels of Exercise

Eligibility Criteria

Sex: All

Age: 18 - 35

Healthy Volunteers: Accepted

Interventions

Handgrip Training

Study Details

Brief summary:

This study aims to investigate the effect of isometric handgrip training on brain blood vessel function in physically inactive adults. Isometric handgrip training is a promising strategy for lowering blood pressure and improving vascular health, but no previous investigations have studied the effect of training on markers of brain blood vessel function. Based on previous work showing improvements in vascular function after isometric handgrip training, we hypothesize that isometric handgrip training will improve key markers of cerebrovascular function.

Conditions

Inactivity/Low Levels of Exercise

Study ID

NCT07223645

Start date

Oct 27, 2025

Status verified date

Jun, 2026

Completion date

Oct 27, 2028

Anticipated

Primary completion date

Oct 27, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 35

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 18 to 35 years old
  • Body mass index ≤30 kg/m2 (without obesity)
  • Physically inactive (not meeting the current recommendations of ≥150 minutes per week of moderate-to-vigorous aerobic exercise and not ≥2 days per week of resistance training) in last 6 months
  • Have a smartphone and are willing to download mobile applications used in this project

Exclusion Criteria:

  • Having an overt chronic condition (e.g., cardiovascular, cerebrovascular, etc.)
  • Being pregnant, planning to become pregnant, or breastfeeding/lactating
  • Regular use of nicotine products in the past 6 months
  • Recent head injury/trauma or concussion

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Isometric Handgrip Training - Intervention

Participants will perform moderate-intensity handgrip training three days per week for eight weeks using a handheld device.

sham comparator: Isometric Handgrip Training - Sham

Participants will perform very low-intensity handgrip training three days per week for eight weeks using a handheld device.

Interventions

Handgrip Training

Handgrip training 3 days per week for 8 weeks

Primary outcome measure

  • Change in middle cerebral artery blood velocity reactivity to hypercapnia [ Time Frame: Up to 9 weeks ]

Central Contacts and Locations

Locations

Florida State University

Recruiting

Tallahassee, Florida, United States, 32306

Contacts

Joseph Watso, PhD

850-644-5260jwatso@fsu.edu

More Information

Sponsor

Florida State University

Last update posted

Jun 25, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Florida State University on 2026-06-25.