Recruiting

Clinical Decision Support

Sponsor:

Washington University School of Medicine

Code:

NCT07223853

Conditions

Surgery

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

S-PATH clinical decision support system

Usual care

Study Details

Brief summary:

20 million patients have surgery in the United States every year, with approximately 1 million of those patients requiring life-saving blood transfusion. Presurgical preparation for transfusion is important to allow for safe and timely transfusion during surgery; however, excessive preparation is unfortunately common, costly, and contributes to blood waste. This study aims to evaluate an intelligent clinical decision support system that helps clinicians prepare blood for patients who are likely to need it, while avoiding excessive preparation for patients who don't, potentially improving patient safety while reducing blood waste and healthcare costs.

Conditions

Surgery

Study ID

NCT07223853

Start date

Oct 28, 2025

Status verified date

Aug, 2026

Completion date

Jan 1, 2027

Anticipated

Primary completion date

Dec 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Clinician Level Exclusion Criteria:

  • Clinician (resident physician or advanced practice provider) who works at a preoperative assessment clinic

Clinician Level Exclusion Criteria:

  • None

Patient Inclusion Criteria:

  • Scheduled for surgery in one of the main operating room areas (non-remote) at Barnes Jewish Hospital
  • Evaluated in-person at one of the preoperative assessment clinics affiliated with BJC Healthcare
  • Have a valid S-PATH model prediction prior to their preoperative assessment clinic visit

Patient Exclusion Criteria:

  • Pregnant
  • Presence or history of red cell alloantibodies

Study Design

Enrollment

50 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Screening

Interventions and Outcome Measures

Arms

active comparator: Usual care

Usual care for determining presurgical blood orders, including use of the institutional Maximum Surgical Blood Ordering Schedule (MSBOS)

experimental: S-PATH

Access to the S-PATH clinical decision support system

Interventions

S-PATH clinical decision support system

Access to the S-PATH electronic health record (EHR)-integrated clinical decision support system

Usual care

Including use of the conventional Maximum Surgical Blood Ordering Schedule (MSBOS)

Primary outcome measure

  • Frequency of patients with a type and screen order placed during the preoperative clinic assessment visit [ Time Frame: Decision made during the preoperative assessment clinic visit ]

Central Contacts and Locations

Central contacts

Sunny S Lou, MD, PhD

314-362-5000slou@wustl.edu

Locations

Washington University / Barnes Jewish Hospital

Recruiting

St Louis, Missouri, United States, 63110

Contacts

Sunny S Lou, MD, PhD

314-362-5000slou@wustl.edu

More Information

Sponsor

Washington University School of Medicine

Last update posted

Aug 27, 2026

Last verified

Aug, 2026

Keywords

  • artificial intelligence
  • clinical decision support
  • machine learning
  • surgery
  • perioperative blood management
  • anesthesia
  • pretransfusion testing

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Washington University School of Medicine on 2026-08-27.