Recruiting

Ultherapy Prime

Sponsor:

The Levine Center for Plastic Surgery

Code:

NCT07224308

Conditions

Laxity; Skin

Eligibility Criteria

Sex: All

Age: 25 - 65

Healthy Volunteers: Accepted

Interventions

Ultherapy Prime

Study Details

Brief summary:

The goal of this clinical trial is to evaluate the long-term safety and effectiveness of Ultherapy Prime (MFU-V) for improving lines, wrinkles, laxity, and crepiness of the lower face, submentum, and neck. The study will enroll adult male and female subjects aged 25-65 with moderate to severe lower-face and neck skin laxity who are appropriate candidates for non-invasive ultrasound treatment.

The main questions this study aims to answer are:

Does Ultherapy Prime delivered at multiple depths compared to a single-depth (1.5 mm) treatment improve clinical lifting, tightening, and smoothing of the lower face and neck over a 12-month period?

Does treatment with Ultherapy Prime stimulate measurable improvements in collagen-related skin quality, patient satisfaction, and investigator-assessed aesthetic outcomes?

Because the study includes two treatment approaches, researchers will compare a multi-depth MFU-V treatment protocol versus a single-depth (1.5 mm) MFU-V treatment protocol to determine whether multi-depth energy delivery provides superior or longer-lasting clinical improvement.

What Participants Will Do

Participants will:

Attend a total of 5 study visits over 12 months (Screening/Treatment, 1-month, 3-month, 6-month, and 12-month follow-ups).

Undergo a single Ultherapy Prime treatment session at either multiple depths or at the 1.5 mm depth only.

Complete standardized photography, including 2D and 3D images, at all timepoints.

Participate in clinical assessments, including GAIS scoring, cutometer elasticity measurements (if applicable), and investigator- and patient-reported satisfaction scales.

Follow pre-visit requirements, including:

No moisturizers, lotions, or topical products on the treatment area before each visit

No hair in the treatment area (shave the day prior if needed)

Complete questionnaires evaluating satisfaction, comfort, and perceived treatment benefits.

Adhere to follow-up schedules, avoiding elective aesthetic procedures to the lower face, submentum, or neck during the study period.

Conditions

Laxity; Skin

Study ID

NCT07224308

Start date

Oct 24, 2025

Status verified date

Oct, 2025

Completion date

Dec 30, 2026

Anticipated

Primary completion date

Nov 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 25 - 65

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Male or female subjects between 25 and 65 years of age at the time of screening.

Presence of moderate to severe laxity, fine lines, or crepiness of the lower face, submentum, and/or neck that is appropriate for improvement with non-invasive MFU-V treatment.

Skin condition not advanced enough to require surgical correction.

Willingness to refrain from elective aesthetic procedures involving the face, submentum, or neck for the entire 12-month duration of the study.

Ability and willingness to comply with all study visits, procedures, and follow-up requirements.

Sufficient English language proficiency to understand study instructions and complete questionnaires.

For participants of childbearing potential: negative urine pregnancy test on the day of treatment and willingness to use adequate contraception during the study.

Ability to provide written informed consent.

Exclusion Criteria:

  • Male or female subjects between 25 and 65 years of age at the time of screening.

Presence of moderate to severe laxity, fine lines, or crepiness of the lower face, submentum, and/or neck that is appropriate for improvement with non-invasive MFU-V treatment.

Skin condition not advanced enough to require surgical correction.

Willingness to refrain from elective aesthetic procedures involving the face, submentum, or neck for the entire 12-month duration of the study.

Ability and willingness to comply with all study visits, procedures, and follow-up requirements.

Sufficient English language proficiency to understand study instructions and complete questionnaires.

For participants of childbearing potential: negative urine pregnancy test on the day of treatment and willingness to use adequate contraception during the study.

Ability to provide written informed consent.

Exclusion Criteria:

Active systemic or local skin disease (e.g., eczema, psoriasis, dermatitis, infection) that may affect wound healing or the evaluation of results.

Scarring, tattoos, or significant pigmentary alterations in the planned treatment areas.

Metallic implants or other implanted electronic devices (e.g., pacemakers) in or near the treatment area.

Open wounds, lesions, active herpes simplex, or active cystic/severe inflammatory acne in the treatment area.

Use of isotretinoin or other oral retinoids within the past 12 months or planned use during the study.

Microdermabrasion or medical-grade glycolic acid treatments to the treatment area within 2 weeks prior to participation.

Deep dermal scarring, thick sebaceous skin, or severe solar elastosis in the treatment area that may interfere with treatment or evaluation.

Intention to gain or lose ≥ 2 BMI units during the 12-month study period.

Known allergy or hypersensitivity to any component of the device or ultrasound coupling gel.

History of chronic drug or alcohol abuse or opioid dependence.

Recent aesthetic procedures to the lower face, submentum, or neck that may confound study outcomes (e.g., fillers, neurotoxins, lasers, threads, RF, ultrasound) within the protocol-specified washout period.

Participation in another clinical study involving an investigational device or drug within 30 days prior to treatment.

Pregnancy, breastfeeding, or plans to become pregnant during the study.

Any condition that, in the opinion of the investigator, would increase risk or interfere with study participation or data interpretation.

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Multi-Depth Ultherapy Prime Treatment

Participants in this arm will receive a single full-face and neck Ultherapy Prime treatment delivered at multiple depths according to the manufacturer's guidelines for MFU-V energy placement. Energy will be applied using the appropriate transducers for each anatomical depth to target multiple layers of tissue beneath the skin surface. The goal is to stimulate collagen production at varying focal points to enhance lifting, tightening, and overall skin quality.

experimental: Single-Depth Ultherapy Prime Treatment (1.5 mm)

Participants in this arm will receive a single full-face and neck Ultherapy Prime treatment delivered exclusively at the 1.5 mm depth, which is one of the FDA-cleared depths for treatment of the lower face and neck. This protocol evaluates whether single-depth energy delivery can achieve meaningful skin improvement compared with multi-layer treatment.

Interventions

Ultherapy Prime

Ultherapy Prime is an FDA-cleared micro-focused ultrasound (MFU-V) device used for non-invasive lifting and tightening of the lower face, submentum, neck, brow, and improvement of décolleté lines. It delivers precise ultrasound energy at controlled depths to create thermal coagulation points that stimulate neocollagenesis, promoting new collagen and elastin for improved firmness and visible lifting. The system includes real-time DeepSEE® imaging to visualize tissue layers and ensure accurate energy placement. Ultherapy Prime uses transducers at FDA-cleared depths such as 1.5 mm, 2.0 mm, 3.0 mm, and 4.5 mm. For this study, treatment is delivered at multiple depths or only at 1.5 mm depending on randomization. It is non-surgical, non-ionizing, does not break the skin, and improvement develops gradually as collagen remodels.

Primary outcome measure

  • Change in Skin Laxity and Wrinkle Severity of the Lower Face and Neck [ Time Frame: Baseline to 3 months post-treatment ]

Central Contacts and Locations

Central contacts

Locations

The Levine Center for Plastic Surgery

Recruiting

New York, New York, United States, 10075

Contacts

More Information

Sponsor

The Levine Center for Plastic Surgery

Last update posted

Nov 4, 2025

Last verified

Oct, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by The Levine Center for Plastic Surgery on 2025-11-04.