Recruiting

MCP-L vs. CBT

Sponsor:

Memorial Sloan Kettering Cancer Center

Code:

NCT07225309

Conditions

Breast Cancer

Prostate Cancer

Colorectal Cancer

Thyroid Cancer

Breast Cancer Stage III

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Meaning-Centered Psychotherapy for Latinos /MCP-L

Study Details

Brief summary:

The purpose of this study is to find out if Meaning-Centered Psychotherapy for Latinos (MCP-L) helps reduce anxiety and depression and improves quality of life compared to cognitive behavioral therapy (CBT). Investigators also want to learn what participants and providers think about the therapy, including how the therapy is designed, outside factors, available resources, and how the people involved affect how well MCP-L works.

Conditions

Breast Cancer

Prostate Cancer

Colorectal Cancer

Thyroid Cancer

Breast Cancer Stage III

Study ID

NCT07225309

Start date

May 1, 2026

Status verified date

Jul, 2026

Completion date

Apr 13, 2029

Anticipated

Primary completion date

Apr 13, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Patient Eligibility Criteria:

A patient cannot be considered eligible for this study unless ALL of the following conditions are met. Participant eligibility will be determined by an initial EMR review followed by a self-report screener and suicide risk assessment.

Inclusion Criteria:

EMR Criteria

\- Documentation of Disease

  • Pathologically confirmed breast, prostate, colorectal, thyroid, cervix, uteri, or lung - solid tumor cancer (either most recent or new diagnosis)

  • Definition of Disease \[or Measurable Disease\]
  • Diagnosed with stages III or IV

  • Prior Treatment
  • Receiving ambulatory care at INCan

Self-Report Criteria

  • Age ≥ 18 years
  • Able to read and communicate in Spanish determined by the question: "Can you read and communicate in Spanish? Yes/No"
  • Professional role of administrators, clinicians (e.g., oncologists), mental health providers, supervised therapists-in-training (e.g., graduate students), or other related provider delivering the MCP-L experimental intervention
  • Providing care (or services) to Mexican cancer patients at INCan
  • Has access to internet and an electronic device
  • Agrees to be audio-recorded

Exclusion Criteria:

EMR Criteria

  • Prior Treatment

  • Received psychological or psychiatric care at INCan in the last 3 months
  • In the judgment of the treating physician, protocol investigators, and/or study staff, presence of cognitive impairment (e.g., delirium or dementia) sufficient to preclude meaningful informed consent and/or study participation
  • Diagnosed with a serious psychiatric condition

Self-Report Criteria

  • Received psychological or psychiatric care outside of INCan in the last 3 months
  • Presence of suicide risk determined by the Columbia-Suicide Severity Rating Scale
  • Too ill to participate determined by the question: "Do you feel too ill to participate because of communication problems, uncontrollable pain, or other symptoms that prevent you from participating?"

Provider Eligibility Criteria:

Inclusion Criteria Self-Report Criteria

  • Age ≥ 18 years
  • Able to read and communicate in Spanish determined by the question: "Can you read and communicate in Spanish? Yes/No"
  • Professional role of administrators, clinicians (e.g., oncologists), mental health providers, supervised therapists-in-training (e.g., graduate students), or other related provider delivering the MCP-L experimental intervention
  • Providing care (or services) to Mexican cancer patients at INCan
  • Has access to internet and an electronic device
  • Agrees to be audio-recorded

Study Design

Enrollment

300 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Experimental Intervention

Meaning-Centered Psychotherapy for Latinos (MCP-L)

no intervention: Control Intervention

Cognitive Behavioral Therapy (CBT)

Interventions

Meaning-Centered Psychotherapy for Latinos /MCP-L

MCP-L is a structured 7-session manualized intervention culturally adapted into Spanish for Latino participants diagnosed with advanced cancer, which utilizes a mixture of didactics, discussion and experiential exercises that focus on particular themes related to meaning and advanced cancer. It is 60-minute individual sessions delivered every week or intermittently (depending on participant preference) for up to approximately 3 months (in this time period) in the event of medical illness.

Primary outcome measure

  • Change in clinical levels of anxiety and depression for participants participating in Meaning-Centered Psychotherapy for Latinos (MCP-L) [ Time Frame: 1 month ]
  • Change in clinical levels of anxiety and depression for participants participating in Meaning-Centered Psychotherapy for Latinos (MCP-L) [ Time Frame: 3 months ]

Central Contacts and Locations

Central contacts

Devika Jutagir, PhD

646-888-8361jutagird@mskcc.org

Francesca Gany, MD, MS

646-888-8054ganyf@mskcc.org

Locations

Memorial Sloan Kettering Cancer Center

Recruiting

New York, New York, United States, 10065

Contacts

Devika Jutagir, PhD

646-888-8361

Principal Investigator:

Devika Jutagir, PhD

More Information

Sponsor

Memorial Sloan Kettering Cancer Center

Last update posted

Aug 3, 2026

Last verified

Jul, 2026

Keywords

  • Breast cancer
  • Breast cancer Stage III
  • Breast cancer Stage IV
  • Prostate cancer
  • Prostate cancer Stage III
  • Prostate cancer Stage IV
  • Colorectal cancer
  • Colorectal cancer Stage III
  • Colorectal cancer Stage IV
  • Thyroid cancer
  • Thyroid cancer Stage III
  • Thyroid cancer Stage IV
  • 25-240
  • Memorial Sloan Kettering Cancer Center

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Memorial Sloan Kettering Cancer Center on 2026-08-03.