Recruiting

Observational Study

Sponsor:

Ohio State University Comprehensive Cancer Center

Code:

NCT07225491

Conditions

Spine Tumor

Spine Metastases

Spine Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This is an observational study to evaluate hardware related and oncologic outcomes in adult patients with primary and metastatic spine disease undergoing separation surgery followed by radiation treatment.

Conditions

Spine Tumor

Spine Metastases

Spine Cancer

Study ID

NCT07225491

Start date

Nov 24, 2025

Status verified date

Dec, 2025

Completion date

Dec 31, 2037

Anticipated

Primary completion date

Dec 31, 2035

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosis of primary or metastatic disease to the spine who undergo surgical decompression and stabilization followed by radiation therapy

Exclusion Criteria:

  • Inability to obtain a standard MRI or CT / CT myelogram for radiation treatment planning and dosimetry
  • Inability to receive radiation treatment.
  • Patients under 18 years of age

Study Design

Enrollment

3000 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Overall survival [ Time Frame: 12, 18, 24 months ]
  • Local control of treated lesion based on radiographic review [ Time Frame: 3, 6, 9, 12, 15, 16, 21, 24 months ]
  • Progression free survival [ Time Frame: 3, 6, 9, 12, 15, 16, 21, 24 months ]

Central Contacts and Locations

Central contacts

Courtney Wright

614-293-4876Courtney.Wright@osumc.edu

Allison Garvin

NeurosurgerySpineResearch@osumc.edu

Locations

University of Michigan

Recruiting

Ann Arbor, Michigan, United States, 48109

Principal Investigator:

Nicholas Szerlip, MD

Rutgers Robert wood Johnson Medical School

Recruiting

New Brunswick, New Jersey, United States, 08901

Principal Investigator:

Jonathan Sherman, MD

The Ohio State University Wexner Medical Center

Recruiting

Columbus, Ohio, United States, 43210

Principal Investigator:

Brad Elder, MD

More Information

Sponsor

Ohio State University Comprehensive Cancer Center

Last update posted

Aug 18, 2026

Last verified

Dec, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Ohio State University Comprehensive Cancer Center on 2026-08-18.