Recruiting

nsPFA Therapy

Sponsor:

M.D. Anderson Cancer Center

Code:

NCT07226804

Conditions

Thyroid Nodules

Pulsed Field Ablation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Questionnaire

Study Details

Brief summary:

To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.

Conditions

Thyroid Nodules

Pulsed Field Ablation

Study ID

NCT07226804

Start date

Nov 14, 2025

Status verified date

May, 2026

Completion date

Aug 31, 2030

Anticipated

Primary completion date

Aug 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Eligibility Criteria

  • Scheduled to undergo ultrasound guided nsPFA as standard of care
  • Age 18 to 80 years.
  • Capable of providing independent consent.
  • Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following:

  • Benign FNA X 2 or
  • Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or
  • Benign FNA X 1 and radiographic/laboratory evidence of functional nature
  • Nodule measuring >2cm in greatest dimension
  • Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress)
  • No abnormal cervical lymph nodes during screening visit .

Exclusion Criteria

  • Age <18
  • Patients considered unsuitable for nsPFA by the treating physician

Study Design

Enrollment

30 participants

Anticipated

Interventions and Outcome Measures

Interventions

Questionnaire

patient-reported outcomes questionnaire

Primary outcome measure

  • Quality-of-life Questionnaire [ Time Frame: Through study completion; an average of 1 year ]

Central Contacts and Locations

Central contacts

Victoria E Banuchi, MD

346-217-8668vebanuchi@mdanderson.org

Locations

MD Anderson Cancer Center

Recruiting

Houston, Texas, United States, 77030

Contacts

Victoria E Banuchi, MD

346-217-8668vebanuchi@mdanderson.org

Principal Investigator:

Victoria E Banuchi, MD

More Information

Sponsor

M.D. Anderson Cancer Center

Last update posted

Jun 1, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by M.D. Anderson Cancer Center on 2026-06-01.