Recruiting

Hypertension Management

Sponsor:

Anita Misra-Hebert

Code:

NCT07232017

Conditions

Hypertension (HTN)

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

IN-HOME BP

Study Details

Brief summary:

The primary objective of the Implementation of Effective Hypertension Management Approaches: Cleveland Clinic program is to improve blood pressure control for patients diagnosed with hypertension (HTN) and uncontrolled blood pressure, specifically defined as a blood pressure greater than 150/95, across all Cleveland Clinic Northeast Ohio primary care practices. The project will scale up the availability of resources for treating hypertension in 56 primary care practices within the Cleveland Clinic Health System in Northern Ohio, reaching up to approximately 3800 patients. This project will utilize evidence from a randomized controlled trial by Margolis et al.(1) to build upon Cleveland Clinic's existing team-based primary care provider (PCP) collaboration with pharmacists and advanced practice providers (APP) and will use a mechanism that allows titrating blood pressure medications based on patient-recorded home blood pressure readings.

Conditions

Hypertension (HTN)

Study ID

NCT07232017

Start date

Jan 6, 2026

Status verified date

Jan, 2026

Completion date

Jul, 2029

Anticipated

Primary completion date

Apr, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Hypertension diagnosis, aged 18-85 years old
  • Uncontrolled blood pressure, defined as a blood pressure reading of > 150/95

Exclusion Criteria:

  • pregnant, stage 5 chronic kidney disease, End Stage Renal Disease, enrolled in hospice care

Study Design

Enrollment

1520 participants

Anticipated

Interventions and Outcome Measures

Arms

IN-HOME BP: titrating BP medications based on patient-recorded home blood pressure readings

This project will utilize evidence from a randomized controlled trial by Margolis et al.(1) to build upon Cleveland Clinic's existing team-based primary care provider (PCP) collaboration with pharmacists and advanced practice providers (APP) and will use a mechanism that allows titrating blood pressure medications based on patient-recorded home blood pressure readings.

Interventions

IN-HOME BP

A team-based approach with a primary care provider (PCP) collaborating with pharmacists and advanced practice providers (APP) and will use a mechanism (frequent follow-up- phone or virtual appointments) that allows titrating blood pressure medications based on patient-recorded home blood pressure readings.

Primary outcome measure

  • Systolic Blood Pressure Change [ Time Frame: Patients will be followed for up to 33 months: 24-month implementation/intervention period and 9-month maintenance period. ]

Central Contacts and Locations

Central contacts

Anita Misra-Hebert, MD, MPH, FACP

216-445-8542MISRAA@ccf.org

Christopher Babuich, MD

440 204-7400babiucc@ccf.org

Locations

Cleveland Clinic

Recruiting

Cleveland, Ohio, United States, 44195

More Information

Sponsor

Anita Misra-Hebert

Last update posted

Jan 9, 2026

Last verified

Jan, 2026

Keywords

  • hypertension
  • uncontrolled blood pressure
  • home blood pressure
  • pharmacist
  • advanced practice provider

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Anita Misra-Hebert on 2026-01-09.