Recruiting

MOUD Evaluation

Sponsor:

Boston University

Code:

NCT07232641

Conditions

Substance Use Disorders

Alcohol Use Disorder

Opioid Use Disorder

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

"Gold-standard" medications for opioid use disorder (MOUD) treatment combines FDA-approved medications, primarily methadone and buprenorphine, with behavioral therapies to provide "whole-patient" treatment. Prior to the pandemic, methadone and buprenorphine were subject to greater federal regulations than medications for other substance use disorders, including medication for alcohol use disorder (MAUD), which created barriers to MOUD initiation and retention. These barriers were exacerbated by physical distancing and diminished clinic capacities during the COVID-19 pandemic. To prevent healthcare disruption and expand access to MOUD treatment during the public health emergency, federal and state authorities implemented several MOUD policy changes during the pandemic to reduce barriers to MOUD initiation and retention, which subsequently became permanent.

This study is an evaluation of the impacts of these policies on treatment use, retention, and patient outcomes pre- and post-MOUD policy implementation.

Conditions

Substance Use Disorders

Alcohol Use Disorder

Opioid Use Disorder

Study ID

NCT07232641

Start date

Jun 30, 2026

Status verified date

Jul, 2026

Completion date

Sep, 2029

Anticipated

Primary completion date

Sep, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Substance use disorder (alcohol and/or opioid) documented in the Veteran's Health Administration Corporate Data Warehouse (CDW)

Exclusion Criteria:

  • None

Study Design

Enrollment

185810 participants

Anticipated

Interventions and Outcome Measures

Arms

VA Patients with substance use disorder

Mutually exclusive groups of patients with OUD and AUD (and no co-occurring OUD), who will be matched 1:1 on age, gender, race, rural/urban residence, and state for the the pre (03/2016-02/2020) and post periods (03/2020-02/2024).

Primary outcome measure

  • Change in MOUD/MAUD Receipt [ Time Frame: 4 years pre/post policy change ]
  • Change in MOUD/MAUD Coverage [ Time Frame: 4 years pre/post policy change ]
  • Change in MOUD/MAUD Retention [ Time Frame: 4 years pre/post policy change ]
  • Change in Behavioral Therapy Receipt [ Time Frame: 4 years pre/post policy change ]
  • Change in Behavioral Therapy Count [ Time Frame: 4 years pre/post policy change ]

Central Contacts and Locations

Central contacts

Nicholas Livingston, PhD

857-364-6612livingn@bu.edu

Locations

VA Medical Center

Recruiting

Boston, Massachusetts, United States, 02130

Contacts

Nicholas Livingston, PhD

857-364-6612livingn@bu.ed

More Information

Sponsor

Boston University

Last update posted

Jul 2, 2026

Last verified

Jul, 2026

Keywords

  • Medications for opioid use disorder (MOUD)

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Boston University on 2026-07-02.