Recruiting

Observational Study

Sponsor:

Healing Advocates Registry and Ministry

Code:

NCT07233148

Conditions

Amyotrophic Lateral Sclerosis (ALS)

Motor Neuron Disease (MND)

Primary Lateral Sclerosis (PLS)

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Education about treatment options

Dietary Supplements: Vitamins, Minerals, Herbs, etc.

Meditation, Prayer, Talk Therapy, Affirmations, Journaling, etc.

Diet, various diets will be observed

Exercise, physical therapy, occupational therapy, speech therapy, sauna, EMS, massage and other therapies

Study Details

Brief summary:

This is a prospective, observational, online study of people diagnosed with ALS, MND or PLS referred to as HAROS (Healing ALS Registry Observational Study). Participants will enter information into an online ALS registry once per month, including their ALSFRS-R data, certain other symptoms, dietary intake, supplements, medications and other therapies, both conventional and integrative. Participants will also enter the hours spent on optional self-study and free online education. The investigators will assess the effectiveness of various therapies and education by measuring physical outcomes.

Conditions

Amyotrophic Lateral Sclerosis (ALS)

Motor Neuron Disease (MND)

Primary Lateral Sclerosis (PLS)

Study ID

NCT07233148

Start date

Jan 26, 2026

Status verified date

Jun, 2026

Completion date

Mar 31, 2036

Anticipated

Primary completion date

Feb 5, 2036

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosed with ALS, MND or PLS

Exclusion Criteria:

  • Smokers

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

ALS/MND less than 3 years since diagnosis

Those diagnosed with ALS, Amyotrophic Lateral Sclerosis or MND, Motor Neuron Disease (other countries) and time since diagnosis is less 3 years, or 36 months, as of the date they join the study.

PLS less than 3 years since diagnosis

Those diagnosed with PLS, Primary Lateral Sclerosis, and time since diagnosis is less 3 years, or 36 months, as of the date they join the study.

ALS/MND 3 years or greater since diagnosis

Those diagnosed with ALS, Amyotrophic Lateral Sclerosis or MND, Motor Neuron Disease (other countries) and time since diagnosis is 3 years or greater as of the date they join the study.

PLS 3 years or greater since diagnosis.

Those diagnosed with PLS, Primary Lateral Sclerosis and time since diagnosis is 3 years or greater as of the date they join the study.

Interventions

Education about treatment options

Education about treatment options and integrative therapies is optional. It is available online and is free for all study participants.

Dietary Supplements: Vitamins, Minerals, Herbs, etc.

The investigators are observing type and quantity of dietary supplements, vitamins, minerals and herbs that ALS/MND/PLS patients take regularly.

Meditation, Prayer, Talk Therapy, Affirmations, Journaling, etc.

Many of those diagnosed with ALS/MND/PLS regularly engage in meditation, prayer and other behavioral protocols. These will be observed and analyzed to see if, and to what degree they affect outcomes.

Diet, various diets will be observed

May ALS/MND/PLS patients follow a specific diet such as ketogenic, vegetarian, gluten-free, dairy-free, and/or sugar-free. The investigators will analyze which diets are most efficacious.

Exercise, physical therapy, occupational therapy, speech therapy, sauna, EMS, massage and other therapies

Exercise, physical therapy, occupational therapy, speech therapy, sauna, massage, EMS (electro-muscular stimulation), red light therapy and other physical modalities will be observed and analyzed for effect on outcomes.

ALS medications and other medications

Many ALS/MND/PLS patients find benefit from prescription and other drugs. These will be observed and analyzed for effect on quality of life and outcomes.

Physical and emotional support

Study participants are asked to record the level of emotional and physical support they get from family members, caregivers, friends, medical professionals and members of their community. The investigators will analyze how the perceived level of emotional and physical support affect outcomes.

Primary outcome measure

  • ALSFRS-R ALS Functional Rating Scale - Revised [ Time Frame: Participants will be assessed at baseline and each 1 year anniversary from the baseline until participant withdraws from the study for any reason, including death from any cause, up to a maximum of 10 years from baseline. ]
  • ALSSQ ALS Supplementary Questionnaire [ Time Frame: Participants will be assessed at baseline and each 1 year anniversary from the baseline until participant withdraws from the study for any reason, including death from any cause, up to a maximum of 10 years from baseline. ]
  • Mindset Score [ Time Frame: Participants will be assessed at baseline and each 1 year anniversary from the baseline until participant withdraws from the study for any reason, including death from any cause, up to a maximum of 10 years from baseline. ]

Central Contacts and Locations

Central contacts

Healing ALS Study Administrator

1-973-714-4621Study@HealingALS.org

Locations

Virtual

Recruiting

Park City, Utah, United States, 84098

Contacts

Healing ALS Study Administrator

1-973-714-4621study@healingals.org

More Information

Sponsor

Healing Advocates Registry and Ministry

Last update posted

Jun 24, 2026

Last verified

Jun, 2026

Keywords

  • ALS
  • PLS
  • MND
  • Amyotrophic Lateral Sclerosis
  • Primary Lateral Sclerosis
  • Motor Neuron Disease
  • Motor Neurone Disease

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-11. This information was provided to ClinicalTrials.gov by Healing Advocates Registry and Ministry on 2026-06-24.