Recruiting

Peanuts with GLP-1

Sponsor:

Ian J. Neeland, MD

Code:

NCT07244458

Conditions

Dietary Change

Obesity & Overweight

Food Acceptance

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

Peanuts

Dual-energy X-ray absorptiometry (DEXA) scans

Study Details

Brief summary:

This study will look at how eating peanuts every day might affect participants weight, how healthy their diet is, and how they feel when eating. Investigators want to see if adding peanuts to meals for 12 weeks helps participants feel fuller, have more energy, and improve body composition. The study will include adults who have been taking GLP-1 medicines like semaglutide or tirzepatide for at least three months. Investigators also want to see if eating peanuts improves overall diet quality and health markers like tiredness and certain levels in blood.

Conditions

Dietary Change

Obesity & Overweight

Food Acceptance

Study ID

NCT07244458

Start date

Apr 20, 2026

Status verified date

Apr, 2026

Completion date

Dec, 2027

Anticipated

Primary completion date

Dec, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Individuals with a BMI ≥30 kg/m2 or with a BMI ≥27 kg/m2 with at least one weight-related comorbidity who have been using semaglutide or tirzepatide for a clinical indication or at least 6 months

Exclusion Criteria:

  • No use or contraindication to use of a GLP-1 RA
  • Known allergy to nuts
  • Pregnant or breastfeeding
  • Incarcerated

Study Design

Enrollment

64 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Peanut Group

Participants in this group will eat 2 ounces, or 53 grams of dry-roasted, lightly salted (low sodium) each day along with their regular diet.

active comparator: No Peanut Group

Participants in this group will continue eating regular diet without peanuts.

Interventions

Peanuts

Participants will eat 2 ounces, or about 53 grams, of dry-roasted, lightly salted peanuts each day along with their regular diet

Dual-energy X-ray absorptiometry (DEXA) scans

DEXA scans will be used to measure body fat

Primary outcome measure

  • Change is Satiety as measured by the Hunger and Satiety Visual Analog Scales (VAS) [ Time Frame: Baseline, End of study (12 weeks) ]
  • Change in fatigue as measured by the Fatigue Severity VAS-F Survey [ Time Frame: Baseline, End of study (12 weeks) ]
  • Change in mood/well-being as measured by the Mental clarity, energy levels, and motivation VAS. [ Time Frame: Baseline, End of study (12 weeks) ]
  • Change in dietary quality as measured by Healthy Eating Index (HEI) [ Time Frame: Baseline, End of study (12 weeks) ]
  • Change in food enjoyment as measured by the Food Pleasure Scale (FPS) [ Time Frame: Baseline, End of study (12 weeks) ]
  • Change in fasting glucose as measured by medical record review [ Time Frame: Baseline, End of study (12 weeks) ]
  • Change in HbA1c as measured by medical record review [ Time Frame: Baseline, End of study (12 weeks) ]
  • Change in total cholesterol as measured by medical record review [ Time Frame: Baseline, End of study (12 weeks) ]
  • Change in LDL-C as measured by medical record review [ Time Frame: Baseline, End of study (12 weeks) ]
  • Change in HDL-C as measured by medical record review [ Time Frame: Baseline, End of study (12 weeks) ]
  • Change in triglycerides as measured by medical record review [ Time Frame: Baseline, End of study (12 weeks) ]
  • Change in physical activity as measured by International Physical Activity Questionnaire (IPAQ) [ Time Frame: Baseline, End of study (12 weeks) ]

Central Contacts and Locations

Central contacts

Ian Neeland, MD

216-844-5965Ian.Neeland@UHhospitals.org

Abigail Raffner, PhD, RD, LD

216-368-0756Abigail.Raffner@UHhospitals.org

Locations

University Hospitals Cleveland Medical Center

Recruiting

Clevland, Ohio, United States, 44106

Contacts

Ian Neeland, MD

216-844-5965Ian.Neeland@UHhospitals.org

Abigail Raffner, PhD, RD, LD

216-368-0756Abigail.Raffner@UHhospitals.org

More Information

Sponsor

Ian J. Neeland, MD

Last update posted

Apr 23, 2026

Last verified

Apr, 2026

Keywords

  • Dietary quality
  • Eating enjoyment
  • Satiety
  • Weight-related outcomes

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Ian J. Neeland, MD on 2026-04-23.