Recruiting
Phase 3

Inflammation Prediction

Sponsor:

Ottawa Heart Institute Research Corporation

Code:

NCT07245849

Conditions

Pericarditis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

18F-FDG PET/CT

Study Details

Brief summary:

The pericardium is a thin, double-layered sac around the heart that helps reduce friction as the heart moves. When this sac gets inflamed, it is called pericarditis, which can cause serious health problems and even be life-threatening. Pericarditis often comes back after the first episode. About 10-30% of people will have it again, and half of those will have it multiple times. Although there are treatments available, they are costly and not often used because we can't predict who best to use them on. Finding a way to predict which patients would benefit from these treatments could help reduce the burden on patients and the healthcare system.

This study will use a test called an 18F-FDG PET/CT with CTA Scan (18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) with computer tomography angiography (CTA)) to measure inflammation in the pericardium.

The purpose of the study is to create easy-to-use tools for doctors to identify people at high risk of pericarditis coming back, so they can get advanced treatment early. This study will help fill knowledge gaps about key predictors like clinical signs, blood tests, and imaging results.

Conditions

Pericarditis

Study ID

NCT07245849

Start date

Jun 17, 2026

Status verified date

Nov, 2026

Completion date

Jul, 2027

Anticipated

Primary completion date

Feb, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. History of recurrent pericarditis\* (i.e. presentation of at lease 2nd episode of acute pericarditis).
2. Age >/= 18 years
3. Given informed consent

  • standard definitions will be used to define an episode of pericarditis. Pericarditis will be diagnosed by using available published criteria, which includes typical pericardial chest pain, pericardial friction rubs, widespread ST segment elevation or PR-segment depression that was not previously reported and new or worsening pericardial effusion on echocardiography. A clinical diagnosis of acute pericarditis will be made when at least 3 of these criteria are present.

Exclusion Criteria:

1. severe valve disease requiring intervention
2. claustrophobia that precludes FDG/PET or CMR imaging
3. pregnancy (all women of child bearing potential will have a negative BHCG test)
4. breastfeeding
5. glomerular filtration rate (GFR) <50 m/min/1.72m2

Study Design

Enrollment

44 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: Recurrent pericarditis

This is a single arm study. Participants enrolled will complete blood and imaging tests.

Interventions

18F-FDG PET/CT

The participants will under an 18F-FDG PET/CT with CTA.

Primary outcome measure

  • Pericardial contrast uptake on late gadolinium enhancement (LGE) on CMR [ Time Frame: At Baseline ]
  • Circumferential linear increased FDG signal uptake [ Time Frame: baseline ]
  • Recurrent pericarditis [ Time Frame: From baseline to 1 year ]

Central Contacts and Locations

Central contacts

Kevin Boczar, MD

613-696-7083KBoczar@ottawaheart.ca

Ashley Cowan, RN

pmacphee@ottawaheart.ca

Locations

University of Ottawa Heart Institute

Recruiting

Ottawa, Ontario, Canada, K1Y 4W7

Contacts

Ashley Cowan, RN

6136967000

More Information

Sponsor

Ottawa Heart Institute Research Corporation

Last update posted

Nov 3, 2026

Last verified

Nov, 2026

Keywords

  • PET
  • pericarditis
  • FDG

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-04. This information was provided to ClinicalTrials.gov by Ottawa Heart Institute Research Corporation on 2026-11-03. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.