Recruiting

Electrical Impedance Tomography

Sponsor:

University of Colorado, Denver

Code:

NCT07247474

Conditions

Neonates and Preterm Infants

Cardiopulmonary

Eligibility Criteria

Sex: All

Age: 0 - 25

Healthy Volunteers: Accepted

Interventions

Electrical impedance tomography (EIT)

Study Details

Brief summary:

This study plans to learn more about ways to look at participant's lungs using new machines called Electrical Impedance Tomography (EIT). The EIT does not use harmful radiation like CT or x-ray. It is read through electrodes like using EKG reading heartbeats.

The investigators want to compare the results of patients who have chronic respiratory disease to patients without chronic respiratory disease to learn more about lung structure and composition.

Conditions

Neonates and Preterm Infants

Cardiopulmonary

Study ID

NCT07247474

Start date

Jan 30, 2026

Status verified date

Feb, 2026

Completion date

Dec, 2028

Anticipated

Primary completion date

Nov, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 25

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 2 weeks to 25 years of age
  • evidence of cardiopulmonary disease including, but not limited to:

1. Post-prematurity respiratory disease
2. Congenital diaphragmatic hernia
3. Pulmonary Hypertension
4. Congenital heart disease
5. Respiratory failure
6. Neuromuscular Disease
7. Developmental or congenital lung disease

OR matched healthy controls (born at term gestation (>36 weeks gestational age) with no cardiopulmonary disease)

Exclusion Criteria:

  • <2 weeks of age
  • Anything that interferes with lead placement on the chest wall (such as, dermatologic conditions, multiple chest tubes, anatomic abnormality, or large dressings that cannot be moved)
  • No informed consent
  • Pregnant or lactating
  • Pacemaker or other metal intrathoracic surgical implant (causes noise in the data)

Study Design

Enrollment

140 participants

Anticipated

Interventions and Outcome Measures

Arms

Cardiopulmonary disease

Have evidence of cardiopulmonary disease including, but not limited to:

  • Post-prematurity respiratory disease
  • Congenital diaphragmatic hernia
  • Pulmonary hypertension
  • Congenital heart disease
  • Respiratory failure
  • Neuromuscular disease
  • Developmental or congenital lung disease

May be imaged with two machines

Control

matched healthy controls with no cardiopulmonary disease

Interventions

Electrical impedance tomography (EIT)

Electrical impedance tomography (EIT) is a noninvasive and non-ionizing imaging technique that describes lung ventilation and perfusion

Primary outcome measure

  • EIT Imaging Maps that provide information about regional ventilation and perfusion of the lung [ Time Frame: 4 hours ]

Central Contacts and Locations

Central contacts

Katelyn Enzer, MD

7207779137allison.keck@childrenscolorado.org

Allison Keck, BS

720-777-0734allison.keck@childrenscolorado.org

Locations

Children's Hospital Colorado

Recruiting

Aurora, Colorado, United States, 80045

Contacts

Allison Keck

720-777-0734allison.keck@childrenscolorado.org

Principal Investigator:

Katelyn Enzer, MD

More Information

Sponsor

University of Colorado, Denver

Last update posted

Feb 23, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Colorado, Denver on 2026-02-23.