Recruiting

GLP-1/GIP

Sponsor:

Medical University of South Carolina

Code:

NCT07251803

Conditions

Gastric Retention

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Gastric Ultrasound

Study Details

Brief summary:

This study will enroll patients 18 years and older who are taking a GLP-1/GIP medication and 1) are scheduled for elective surgery and meet ASA fasting guidelines (nothing by mouth for at least 8 hours prior), or 2) scheduled elective colonoscopy and have been on a clear liquid diet for at least 24 hours prior. Participants will have a gastric ultrasound prior to surgery to measure any retained gastric contents. The purpose of this study is to determine if people taking GLP-1 receptor agonists and who fast normally are at an equal risk for having retained gastric contents after appropriately fasting for surgery, compared to patients who are on a liquid only diet for 24 hours prior to surgery.

Conditions

Gastric Retention

Study ID

NCT07251803

Start date

Feb 3, 2026

Status verified date

Feb, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18+
  • Have taken a GLP-1 or GLP-GIP agonist medication within the past 30 days
  • ASA Physical Classification Status 1-3
  • Fall into one of the following groups:

1. Scheduled elective surgery and meet ASA fasting guidelines (NPO for at least 8 hours prior)
2. Scheduled elective colonoscopy and have been on a clear liquid diet for at least 24 hours prior

Exclusion Criteria:

  • Previous gastric or esophageal surgery
  • Abnormal gastric anatomy
  • Pregnancy
  • Unable to provide written, informed consent
  • Non-English speaking

Study Design

Enrollment

150 participants

Anticipated

Interventions and Outcome Measures

Arms

ASA fasting guidelines

Scheduled elective surgery and meet ASA fasting guidelines (NPO for at least 8 hours prior)

24-hour clear liquid diet

Scheduled elective colonoscopy and have been on a clear liquid diet for at least 24 hours prior

Interventions

Gastric Ultrasound

All participants will undergo a gastric ultrasound in the preoperative area prior to their scheduled procedure. The patient will be placed in supine position. A curvilinear ultrasound probe will be placed on the sagittal plane below the xiphoid process. The probe will then slide along the costal margin to the right until the gastric antrum is identified. At this point, the ultrasound image will be obtained, and appropriate measurements will be taken. The patient will be placed in the right lateral decubitus position (RLD), and the above procedure will be repeated. The measurement of gastric antral cross-sectional area while in the RLD position will be recorded and used to calculate the gastric volume.

Primary outcome measure

  • Pre-operative gastric volume per unit of weight (ml/kg) as assessed by gastric ultrasound. [ Time Frame: From enrollment until completion of pre-operative gastric ultrasound (typically within 3 hours of scheduled procedure). ]

Central Contacts and Locations

Central contacts

Haley Nitchie, MHA

843-792-1869nitchie@musc.edu

Locations

Medical University of South Carolina

Recruiting

Charleston, South Carolina, United States, 29425

Contacts

Haley Nitchie, MHA

843-792-1869nitchie@musc.edu

Principal Investigator:

Christopher Wolla, M.D.

More Information

Sponsor

Medical University of South Carolina

Last update posted

Feb 25, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Medical University of South Carolina on 2026-02-25.