Recruiting

DSLT

Sponsor:

Mann Eye Institute

Code:

NCT07281391

Conditions

Pigmentary Dispersion Syndrome

Pigmentary Dispersion Glaucoma

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

Voyager DSLT

Study Details

Brief summary:

This study is a single-site, single-arm, prospective, observational study of IOP reduction after DSLT. Subjects will be assessed up to 12 months post-operatively. Clinical evaluations will include IOP and number of glaucoma medications.

Conditions

Pigmentary Dispersion Syndrome

Pigmentary Dispersion Glaucoma

Study ID

NCT07281391

Start date

Mar 19, 2026

Status verified date

Apr, 2026

Completion date

Apr 1, 2027

Anticipated

Primary completion date

Apr 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adult patients with pigmentary dispersion syndrome with elevated IOP or mild to moderate (based on AAO Preferred Practice Program criteria) pigmentary glaucoma with glaucomatous optic neuropathy and corresponding visual field/RNFL loss.
  • Treatment naive, or washed out IOP ranging from ≥18-34 mmHg
  • Central corneal thickness (CCT) 480-600 µm
  • Able to complete medication washout and follow-up

Exclusion Criteria:

  • Prior incisional glaucoma surgery or glaucoma-related procedures in the study eye
  • Prior laser trabeculoplasty <3 years
  • Prior intraocular surgery and refractive surgery, except for cataract surgery unless greater than 2 years
  • Patients anticipating cataract surgery within the follow-up period
  • History of ocular inflammation and infection
  • All other secondary glaucoma including exfoliative
  • Patients unable to have DSLT treatment

Study Design

Enrollment

45 participants

Anticipated

Interventions and Outcome Measures

Interventions

Voyager DSLT

DSLT is an innovative adaptation of traditional SLT. Rather than using a gonioscopic lens, DSLT applies laser energy directly through the limbus to the trabecular meshwork in a few seconds.

Primary outcome measure

  • Mean washed-out IOP change post-DSLT compared to washed-out baseline IOP [ Time Frame: 6 months post-DSLT ]

Central Contacts and Locations

Central contacts

Melissa Wright

713-580-2500Melissa.Wright@manneye.com

Locations

Mann Eye Institute

Recruiting

Houston, Texas, United States, 76134-2099

Contacts

Melissa Hamann Wright

713-580-2500Melissa.Wright@manneye.com

Principal Investigator:

Alex Hacopian, MD

More Information

Sponsor

Mann Eye Institute

Last update posted

Apr 9, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Mann Eye Institute on 2026-04-09.