Recruiting
Phase 3

Eloralintide

Sponsor:

Eli Lilly and Company

Code:

NCT07282600

Conditions

Overweight

Obesity

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Eloralintide

Placebo

Study Details

Brief summary:

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks.

Conditions

Overweight

Obesity

Study ID

NCT07282600

Start date

Dec 15, 2025

Status verified date

Aug, 2026

Completion date

Feb, 2028

Anticipated

Primary completion date

Jan, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Have type 2 diabetes
  • Are on stable treatment for type 2 diabetes for at least 90 days prior to screening
  • Have a BMI ≥ 27 kg/m2
  • Have a stable body weight (<5% body weight change) for 90 days prior to screening

Exclusion Criteria:

  • Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening)
  • Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
  • Have type 1 diabetes
  • Have taken any of the following antihyperglycemic medications within 90 days before screening:

  • amylin analogs
  • glucagon-like peptide-1 (GLP-1) receptor agonists
  • glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP) receptor agonists, or
  • insulin
  • Have had within 90 days prior to screening:

  • heart attack
  • stroke
  • coronary artery revascularization
  • unstable angina, or
  • hospitalization due to congestive heart failure
  • Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
  • Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Study Design

Enrollment

1035 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Eloralintide Dose 1

Participants will receive eloralintide subcutaneously (SC)

experimental: Eloralintide Dose 2

Participants will receive eloralintide SC

experimental: Eloralintide Dose 3

Participants will receive eloralintide SC

experimental: Eloralintide Dose 4

Participants will receive eloralintide SC

placebo comparator: Placebo

Participants will receive placebo SC

Interventions

Eloralintide

Administered SC

Placebo

Administered SC

Primary outcome measure

  • Percent Change from Baseline in Body Weight [ Time Frame: Baseline, Week 64 ]

Central Contacts and Locations

Central contacts

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

317-615-4559LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact

clinical_inquiry_hub@lilly.com

Locations

Birmingham Clinical Research

Recruiting

Birmingham, Alabama, United States, 35209

Contacts

205-870-4343

Principal Investigator:

Nova Law

Cullman Clinical Trials

Recruiting

Cullman, Alabama, United States, 35055

Contacts

256-708-2826

Principal Investigator:

Randall Quinn

Tucson Clinical Research Institute

Recruiting

Tucson, Arizona, United States, 85712

Principal Investigator:

Girish Karamchandani

San Fernando Valley Health Institute

Recruiting

Canoga Park, California, United States, 91304

Contacts

818-222-6868

Principal Investigator:

Jeffrey London

AMCR Institute

Recruiting

Escondido, California, United States, 92025

Contacts

760-466-1520

Principal Investigator:

Jenine Stone

NorCal Medical Research, Inc

Recruiting

Greenbrae, California, United States, 94904

Contacts

415-461-1585

Principal Investigator:

Linda Gaudiani

Ark Clinical Research

Recruiting

Long Beach, California, United States, 90815

Principal Investigator:

Martha Navarro

Pacific Clinical Studies

Recruiting

Los Alamitos, California, United States, 90720

Contacts

562-598-0600 ext 205

Principal Investigator:

Etsegenet Ayele

Inglewood Clinical

Recruiting

Los Angeles, California, United States, 90056

Contacts

310-693-5000

Principal Investigator:

Maricor Grio

Care Access - Santa Clarita

Recruiting

Santa Clarita, California, United States, 91321

Contacts

661-371-7272

Principal Investigator:

Sina Tebi

Encompass Clinical Research

Recruiting

Spring Valley, California, United States, 91978

Contacts

619-660-9068

Principal Investigator:

Hanid Audish

Diablo Clinical Research, Inc.

Recruiting

Walnut Creek, California, United States, 94598

Contacts

925-930-7267

Principal Investigator:

Bonnie Kimmel

Care Access - Aurora

Recruiting

Aurora, Colorado, United States, 80012

Contacts

720-368-4865

Principal Investigator:

Mauricio Waintrub

New England Research Associates, LLC

Recruiting

Bridgeport, Connecticut, United States, 06606

Contacts

203-374-9816

Principal Investigator:

Ilja Hulinsky

CMR of Greater New Haven, LLC

Recruiting

Hamden, Connecticut, United States, 06517

Principal Investigator:

Jillian Reid

Arrow Clinical Trials

Recruiting

Daytona Beach, Florida, United States, 32117

Contacts

386-278-8000

Principal Investigator:

David Billmeier

Care Access - Delray Beach

Recruiting

Delray Beach, Florida, United States, 33484

Contacts

401-773-7855

Principal Investigator:

Sudhir Bansal

Fleming Island Center for Clinical Research

Recruiting

Fleming Island, Florida, United States, 32003

Contacts

904-621-0390

Principal Investigator:

Jennifer Sidey

Nature Coast Clinical Research - Inverness

Recruiting

Inverness, Florida, United States, 34452

Contacts

352-341-2100

Principal Investigator:

Paul Hellstern

Jacksonville Center for Clinical Research

Recruiting

Jacksonville, Florida, United States, 32216

Contacts

904-730-0101

Principal Investigator:

Jeffry Jacqmein

Flourish Research Acquisition, LLC dba Flourish Research - North Miami

Recruiting

Miami, Florida, United States, 33138

Contacts

786-772-0411

Principal Investigator:

Rimsky Denis

New Horizon Research Center

Recruiting

Miami, Florida, United States, 33165

Contacts

305-226-3933

Principal Investigator:

Lazaro Nunez

Adult Medicine of Lake County, Inc.

Recruiting

Mt. Dora, Florida, United States, 32757

Contacts

352-383-8222

Principal Investigator:

Shirley Nagel

American Research Centers of Florida

Recruiting

Pembroke Pines, Florida, United States, 33027

Contacts

954-237-3799

Principal Investigator:

Luis del Prado Rodriguez

Clinical Site Partners, LLC dba Flourish Research

Recruiting

Winter Park, Florida, United States, 32789

Contacts

407-740-8078

Principal Investigator:

Monica Aggarwal

Teak Research Consults - Dunwoody

Recruiting

Dunwoody, Georgia, United States, 30338

Contacts

470-403-4755

Principal Investigator:

Aakar Thaker

Teak Research Consults

Recruiting

Lawrenceville, Georgia, United States, 30043

Principal Investigator:

Kamar Alabi

The Jones Center Clinical Research

Recruiting

Macon, Georgia, United States, 31210

Principal Investigator:

Susan Garcia Castillo

Pacific Diabetes & Endocrine Center

Recruiting

Honolulu, Hawaii, United States, 96817

Contacts

808-526-0303

Principal Investigator:

ALAN PARSA

NorthShore University Health System

Recruiting

Skokie, Illinois, United States, 60077

Contacts

847-663-8540

Principal Investigator:

Liana Billings

DM Clinical Research - Indianapolis

Recruiting

Indianapolis, Indiana, United States, 46254

Contacts

463-271-3050

Principal Investigator:

Brandon Essink

Clinical Trials Management, LLC d/b/a Flourish Research

Recruiting

Metairie, Louisiana, United States, 70006

Contacts

504-455-1310

Principal Investigator:

David Dulitz

IMA Clinical Research Monroe - Armand

Recruiting

Monroe, Louisiana, United States, 71201

Principal Investigator:

Clinton Guillory

Centennial Medical Group

Recruiting

Columbia, Maryland, United States, 21045

Contacts

410-730-3399

Principal Investigator:

Rajiv Dua

Lucida Clinical Trials

Recruiting

New Bedford, Massachusetts, United States, 02740

Contacts

508-720-2015

Principal Investigator:

David Shih

Clinical Research Professionals

Recruiting

Chesterfield, Missouri, United States, 63005

Contacts

636-220-1200

Principal Investigator:

Timothy Jennings

Clinvest Headlands Llc

Recruiting

Springfield, Missouri, United States, 65807

Contacts

417-883-7889

Principal Investigator:

Cory Bethmann

Hypertension & Nephrology Association

Recruiting

Eatontown, New Jersey, United States, 07724

Principal Investigator:

spiros Arbes

IMA Clinical Research Warren

Recruiting

Warren Township, New Jersey, United States, 07059

Principal Investigator:

Nancy Phillips

Albuquerque Clinical Trials, Inc.

Recruiting

Albuquerque, New Mexico, United States, 87102

Contacts

505-224-7407

Principal Investigator:

Satkirin Khalsa

NYC Research INC

Recruiting

Long Island City, New York, United States, 11106

Contacts

516-574-9232

Principal Investigator:

Anastasios Manessis

PharmQuest Life Sciences, LLC

Recruiting

Greensboro, North Carolina, United States, 27408

Contacts

336-574-8020

Principal Investigator:

Alexander Murray

West Clinical Research

Recruiting

Morehead City, North Carolina, United States, 28557

Contacts

252-515-0050

Principal Investigator:

Patrick Morgante

Trial Management Associates - Wilmington - Floral Parkway

Recruiting

Wilmington, North Carolina, United States, 28403

Principal Investigator:

William Jones

Lillestol Research

Recruiting

Fargo, North Dakota, United States, 58104

Contacts

701-232-7705

Principal Investigator:

Michael Lillestol

Care Access - Lima

Recruiting

Lima, Ohio, United States, 45805

Principal Investigator:

Jimmy Alele

Summit Headlands

Recruiting

Portland, Oregon, United States, 97210

Principal Investigator:

Andre Barkhuizen

Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair

Recruiting

Pittsburgh, Pennsylvania, United States, 15243

Contacts

412-942-0023

Principal Investigator:

Daniel Austin

Preferred Primary Care Physicians

Recruiting

Uniontown, Pennsylvania, United States, 15401

Contacts

724-438-1479

Principal Investigator:

Richard Cook II

Accellacare - Mt Pleasant

Recruiting

Mt. Pleasant, South Carolina, United States, 29464

Contacts

843-849-1880

Principal Investigator:

Richard Mills

IMA Clinical Research Austin

Recruiting

Austin, Texas, United States, 78745

Principal Investigator:

Yu-Mei Liu

Private Practice - Dr. Osvaldo A. Brusco

Recruiting

Corpus Christi, Texas, United States, 78414

Contacts

361-885-0448

Principal Investigator:

Osvaldo Brusco

Velocity Clinical Research, Dallas

Recruiting

Dallas, Texas, United States, 75230

Principal Investigator:

Dan Lender

Diabetes and Thyroid Center of Ft. Worth

Recruiting

Fort Worth, Texas, United States, 76132

Contacts

817-263-0007

Principal Investigator:

Anjanette Tan

Juno Research

Recruiting

Houston, Texas, United States, 77040

Contacts

713-779-5494

Principal Investigator:

Damaris Vega

Southern Endocrinology Associates

Recruiting

Mesquite, Texas, United States, 75149

Contacts

214-693-0904

Principal Investigator:

Sumana Gangi

Research Your Health

Recruiting

Plano, Texas, United States, 75093

Contacts

9729991155 x103

Principal Investigator:

Michele Reynolds

IMA Clinical Research San Antonio

Recruiting

San Antonio, Texas, United States, 78229

Contacts

210-692-7157

Principal Investigator:

Priscilla Thomas

Ogden Clinic - Canyon View

Recruiting

Ogden, Utah, United States, 84404

Contacts

385-271-0684

Principal Investigator:

Stephen Bruce

Diabetes & Endocrine Treatment Specialists

Recruiting

Sandy City, Utah, United States, 84093

Contacts

801-816-1010

Principal Investigator:

Timothy Graham

More Information

Sponsor

Eli Lilly and Company

Last update posted

Aug 21, 2026

Last verified

Aug, 2026

Keywords

  • Type 2 Diabetes

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Eli Lilly and Company on 2026-08-21.