Recruiting

Topographic Classification

Sponsor:

UCLA

Code:

NCT07283042

Conditions

Placenta Accreta

Eligibility Criteria

Sex: Female

Age: 18 - 55

Healthy Volunteers: Not accepted

Interventions

Total Hysterectomy

Modified subtotal hysterectomy

One-Step Conservative Surgery

Study Details

Brief summary:

This study evaluates the clinical implementation of intra-operative topographic classification system for PAS. In addition to a standard of care risk stratification prenatal ultrasound for patients with a risk of PAS, this study adds an additional intraoperative surgical staging protocol to validate the classification system, improve surgical approach, and significantly clinical outcomes of pregnant people with an a prior risk of PAS. The study will involve pregnant patients with PAS risk factor, include data collection spanning prenatal assessment, intraoperative classification, surgical technique implementation and postoperative analysis. The anticipated study duration is approximately 36-48 months.

Conditions

Placenta Accreta

Study ID

NCT07283042

Start date

Dec 1, 2025

Status verified date

Dec, 2025

Completion date

Dec 31, 2028

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 55

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Pregnant people suspected of having PAS based on ultrasound findings or clinical risk factors
  • Patients undergoing planned surgical intervention for PAS, including a planned cesarean
  • Individuals who provide informed consent to participate in the study
  • Patients with at least one prenatal assessment before surgery
  • Expected age range: 18-55
  • Patient has agreed to conservative management approach as part of standard of care if feasible intraoperatively

Exclusion Criteria:

  • Patients who decline participation or withdraw consent
  • Those with contraindications to the planned surgical procedure

Study Design

Enrollment

60 participants

Anticipated

Interventions and Outcome Measures

Arms

PAS

Patients with placental accreta undergoing planned surgical intervention for PAS

Interventions

Total Hysterectomy

Removal of entire uterus

Modified subtotal hysterectomy

When partial tissue integrity is preserved

One-Step Conservative Surgery

Considered when significant healthy myometrium is preserved

Primary outcome measure

  • Ultrasound assessment [ Time Frame: 0-30 days prior to planned surgery ]
  • Surgical Procedure and Classification [ Time Frame: At time of surgery ]
  • Quantification of Blood Loss [ Time Frame: Documented throughout surgery and at the completion of the procedure ]
  • Gross Pathological Analysis of Resected Tissues [ Time Frame: Within 2 hours post surgery ]
  • Adverse Events [ Time Frame: Up to 12 months post surgery ]

Central Contacts and Locations

Central contacts

Dana Levin-Lopez, MPH

310-794-8893dlevinlopez@mednet.ucla.edu

Locations

University of California, Los Angeles

Recruiting

Los Angeles, California, United States, 90095

Contacts

Dana Levin-Lopez, MPH

310-794-8893dlevinlopez@mednet.ucla.edu

Principal Investigator:

Yalda Afshar, MD, PhD

More Information

Sponsor

University of California, Los Angeles

Last update posted

Jan 16, 2026

Last verified

Dec, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of California, Los Angeles on 2026-01-16.