Recruiting

tDCS

Sponsor:

Baycrest

Code:

NCT07291687

Conditions

Progressive Supranuclear Palsy

Cortical Basal Ganglionic Degeneration

Parkinson Disease

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

Transcranial direct current stimulation (TDCS)

Stimulation Arm

Study Details

Brief summary:

Previous preliminary results are sufficiently impressive to suggest that tDCS stimulation does have the potential to improve motor function when that ability is trained during stimulation. In the proposed study, the investigation will assess whether walking sessions combined with tDCS lead to improvements in motor function: gait, articulation, eye gaze, and motor dexterity. In addition, the investigators wish to examine if such results can be replicated in people with other conditions, such as cortical basal syndrome, and Parkinson's disease.

Conditions

Progressive Supranuclear Palsy

Cortical Basal Ganglionic Degeneration

Parkinson Disease

Study ID

NCT07291687

Start date

Oct 30, 2025

Status verified date

Dec, 2025

Completion date

Dec, 2030

Anticipated

Primary completion date

Dec, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

\- 1. Participants must be able to walk unassisted, or with the assistance of a walker or cane, and be individuals who walk daily.

2\. Participants should have a sufficient level of English to be able to express themselves verbally, be able to read and follow instructions.

Exclusion Criteria:

  • 3\. Individuals with metal implants within the brain such as shunts will be excluded.

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Real tDCS Stimulation:

Participants will be exposed to 20 min of tDCS brain stimulation while undergoing training on cognitive tasks.

placebo comparator: Sham Arm

Participants will be exposed to 20 min of tDCS sham/placebo stimulation while undergoing training on cognitive tasks. Participants will have the exact same apparatus used but with no stimulation.

Interventions

Transcranial direct current stimulation (TDCS)

The Crossover design will enable us to use each participant as their own control.

Stimulation Arm

Participants will be exposed to the brain stimulation protocol while undergoing certain motor task during the training sessions.

Primary outcome measure

  • Gait speed [ Time Frame: Measures collected at three points each round: baseline in week 1, post-treatment at the final stimulation session, and follow-up two weeks after the final session. ]

Central Contacts and Locations

Central contacts

Alice Zhang, B.Sc

(416) 785-2500azhang4@research.baycrest.org

Tyler Roncero, Ph.D

T (416) 785-2500croncero@research.baycrest.org

Locations

Baycrest Academy of Health Sciences and Geriatric Research

Recruiting

Toronto, Ontario, Canada, M6A 2E1

More Information

Sponsor

Baycrest

Last update posted

Dec 18, 2025

Last verified

Dec, 2025

Keywords

  • Progressive Supranuclear Palsy (PSP),
  • Cortical basal syndrome (CBD)

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Baycrest on 2025-12-18.