Recruiting

Observational Study

Sponsor:

Colorado State University

Code:

NCT07297823

Conditions

Exercise

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Accepted

Interventions

Cold temperature

Room Temperature

Study Details

Brief summary:

The purpose of this research study is to determine if the cold-induced change in fat burning during exercise is different between females and males.

Conditions

Exercise

Study ID

NCT07297823

Start date

Apr 15, 2026

Status verified date

May, 2026

Completion date

Jun 30, 2027

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age 18-40 years (inclusive)
  • Weight stable (no change in body mass greater than 5 lbs. within the previous 6 months.
  • Willing to abstain from caffeine and alcohol for 24-hours prior to two different study visits
  • Competency in English as informally assessed by comprehension of the Informed Consent. This study involves maximal exercise testing; for safety reasons, the ability for clear and rapid communication will be necessary between the research participants and the investigators.
  • Regular exercise (i.e., at least 150 minutes of moderate-vigorous exercise per week)

Exclusion Criteria:

  • Use of hormonal contraceptives
  • History of autonomic, cardio-pulmonary, and/or metabolic disease (including heart failure, hypertension, arrhythmia, vascular disease, and/or diabetes)
  • Pregnancy or breast feeding
  • Habitual use of tobacco/nicotine products or recreational drugs (2 or more uses within the previous month)

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Other

Interventions and Outcome Measures

Arms

active comparator: Exercise at room temperature

Study participants will ride an exercise bike

experimental: Exercise at cold temperature

Study participants will ride an exercise bike. Room temperature will be 5 ºC

Interventions

Cold temperature

Room temperature will be decreased to 5 ºC

Room Temperature

Exercise condition for control arm

Primary outcome measure

  • Maximal Fat Oxidation [ Time Frame: During exercise while in the lab ]

Central Contacts and Locations

Central contacts

Christopher Bell

9704917522Christopher.Bell@colostate.edu

Christina Cheng

9704913495c.cheng@colostate.edu

Locations

Colorado State University

Recruiting

Fort Collins, Colorado, United States, 80523

Contacts

Christopher Bell, PhD

9704917522christopher.bell@colostate.edu

Taylor Ewell, MS

9704913495Taylor.Ewell@colostate.edu

More Information

Sponsor

Colorado State University

Last update posted

May 15, 2026

Last verified

May, 2026

Keywords

  • exercise
  • fat
  • temperature
  • cold
  • metabolism

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Colorado State University on 2026-05-15.