Recruiting

Lavender Aromatherapy

Sponsor:

Cedars-Sinai Medical Center

Code:

NCT07299474

Conditions

Inferior Turbinate Hypertrophy

Chronic Rhinosinusitis (CRS)

Rhinitis, Vasomotor

Thyroid Nodules

Vocal Fold Immobility

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Lavender Aromatherapy

Placebo Aromatherapy

Study Details

Brief summary:

The purpose of this study is to evaluate the efficacy of lavender aromatherapy in adult patients undergoing awake otolaryngologic procedures in the outpatient clinic setting. The main questions it aims to answer are:

  • Does lavender aromatherapy help reduce anxiety and/or pain, and improve patient comfort during awake otolaryngologic procedures in the clinic?
  • Do patients subjectively find aromatherapy relaxing and/or beneficial during the procedure?

Researchers will compare lavender aromatherapy to placebo (an odorless liquid) to see if lavender aromatherapy helps improve patient comfort during their awake procedure

Participants will:

  • Have their scheduled procedure performed with lavender aromatherapy or placebo during the duration of the procedure
  • Take a short, less than 1 minute questionnaire both before and after the procedure, describing their levels of anxiety, pain and subjective impressions of the aromatherapy

Conditions

Inferior Turbinate Hypertrophy

Chronic Rhinosinusitis (CRS)

Rhinitis, Vasomotor

Thyroid Nodules

Vocal Fold Immobility

Study ID

NCT07299474

Start date

Dec, 2025

Status verified date

Dec, 2025

Completion date

Jan, 2028

Anticipated

Primary completion date

Jan, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adults ≥18 years old undergoing awake otolaryngologic procedures in the outpatient clinic
  • Able to provide informed consent

Exclusion Criteria:

  • Hypersensitivity to fragrances
  • Taking systemic NSAIDs or other systemic pain-relieving medications within 48 hours
  • Taking anxiolytics, hypnotics, sedating antihistamines, antidepressants on regular basis within 4 weeks
  • Pregnant or breastfeeding
  • Participation in another clinical research study within the prior 30 days

Study Design

Enrollment

184 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Lavender Aromatherapy

Participants will be exposed to lavender aromatherapy on a cotton ball prior to procedure, and then with a diffuser during the duration of the procedure

placebo comparator: Placebo

Participants will be exposed to placebo odorless liquid, on a cotton ball prior to procedure, and then with a diffuser during the duration of the procedure

Interventions

Lavender Aromatherapy

Lavender essential oil on cotton ball, and in aromatherapy diffuser

Placebo Aromatherapy

Saline on cotton ball and in aromatherapy diffuser

Primary outcome measure

  • Change in visual analog scale anxiety, measured on a 10 cm scale [ Time Frame: Baseline, Periprocedural and Immediately after the procedure ]
  • Likert scale of pain, measured on a scale of 0-10 [ Time Frame: Immediately after the procedure ]
  • Likert scale subjective improvement with pain, measured on scale of 1-5 [ Time Frame: Immediately after the procedure ]

Central Contacts and Locations

Central contacts

Dhruv S Kothari, MD

310-560-7331dhruv.kothari@cshs.org

Ankona Ghosh, MD

213-300-7972ankona.ghosh@cshs.org

Locations

Cedars-Sinai Medical Center Otolaryngology Clinics

Recruiting

Los Angeles, California, United States, 90048

More Information

Sponsor

Cedars-Sinai Medical Center

Last update posted

Dec 23, 2025

Last verified

Dec, 2025

Keywords

  • Aromatherapy
  • Otolaryngology
  • Awake procedure

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Cedars-Sinai Medical Center on 2025-12-23.