Recruiting

Observational Study

Sponsor:

Brigham and Women's Hospital

Code:

NCT07315997

Conditions

Rheumatoid Arthritis (RA

Atherosclerotic Cardiovascular Disease (ASCVD)

Eligibility Criteria

Sex: All

Age: 35 - 70+

Healthy Volunteers: Not accepted

Interventions

high sensitivity cardiac troponin

Study Details

Brief summary:

Individuals with rheumatoid arthritis (RA) have up to 2x the risk of having a heart attack compared to someone without RA. The goal of this study is to identify biomarkers that can help us do a better job of identifying individuals at risk before they develop symptoms of heart disease and start preventative treatment earlier.

Conditions

Rheumatoid Arthritis (RA

Atherosclerotic Cardiovascular Disease (ASCVD)

Study ID

NCT07315997

Start date

Sep 4, 2024

Status verified date

Dec, 2025

Completion date

Mar 4, 2028

Anticipated

Primary completion date

Mar 4, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 35 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • RA diagnosed by a rheumatologist
  • Age 40- 79
  • ≥1 ASCVD risk factor including prediabetes, hypertension, BMI >30, current or history of cigarette smoking

Exclusion Criteria:

  • Patients on a statin or with a contraindication to statin, on a cholesterol absorption inhibitor, or on a PCSK9 inhibitor
  • Patients with diabetes mellitus
  • Pregnancy

Study Design

Enrollment

120 participants

Anticipated

Interventions and Outcome Measures

Interventions

high sensitivity cardiac troponin

Blood measurement of high sensitivity cardiac troponin

Primary outcome measure

  • coronary artery calcium score [ Time Frame: Cross-sectional, at baseline ]

Central Contacts and Locations

Locations

Massachusetts General Hospital: Rheumatology

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Sheila Arvikar, MD

6177267938sarvikar@mgh.harvard.edu

Abisayo Animashaun, MS

617-732-8169aanimashaun@mgb.org

Principal Investigator:

Sheila Arvikar, MD

Brigham and Womens Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Katherine P Liao, MD, MPH

617-525-8819kliao@bwh.harvard.edu

Abisayo Animashaun, MS

617-732-8169aanimashaun@mgb.org

Principal Investigator:

Katherine P Liao, MD, MPH

Brigham and Women's Faulkner Hospital

Recruiting

Boston, Massachusetts, United States, 02130

Contacts

Nicole Yang, MD

6179837720nyang2@bwh.harvard.edu

Abisayo Animashaun, MS

617-732-8169aanimashaun@mgb.org

Principal Investigator:

Nicole Yang, MD

More Information

Sponsor

Brigham and Women's Hospital

Last update posted

Jul 14, 2026

Last verified

Dec, 2025

Keywords

  • CAT-RA

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Brigham and Women's Hospital on 2026-07-14.