Recruiting

REHIT

Sponsor:

California State University, San Marcos

Code:

NCT07328568

Conditions

Inactivity, Physical

Overweight (BMI > 25)

Healthy Participants

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Interventions

High intensity interval training

Study Details

Brief summary:

Low levels of physical activity (PA) are related to poor health and greater risk of premature death in adults. Lack of time is cited as a primary barrier to partaking in PA. In the last 20 years, a lot of attention has been directed towards the efficacy of high intensity interval training (HIIT), which consists of brief, intense bursts of PA separated by recovery. One primary benefit of HIIT is a sizable increase in cardiorespiratory fitness (CRF), which enables adults to exercise better and reduce health risks due to the strong link between health status and CRF.

Completion of cardiovascular exercise is typically recommended for all adults to increase CRF, yet it takes a lot of time and may be perceived as boring. Alternatively, HIIT requires less time and tends to cause greater feelings of enjoyment in many adults. Hundreds of studies report an increase in CRF in response to HIIT in various groups of adults ranging from athletes and those with obesity, diabetes, cancer, stroke, and even spinal cord injury, which emphasizes the potency of this vigorous form of PA. Yet, many studies are weakened by a small sample size which questions the feasibility of these findings.

This randomized controlled trial will test the efficacy and feasibility of a very small amount of HIIT, referred to as reduced exertion high intensity interval training (REHIT), in inactive adults. In the proposed study, REHIT will consist of 2 days per week of 1 to two 10 - 20 second sprints on a stationary bike. The proposed sample will include 60 adults who complete 18 sessions of REHIT over a 9 week period, and their responses will be compared to a non exercising control group. During the study, changes in CRF, fuel metabolism, and psychological responses will be monitored, with the latter outcome shedding light on the overall feasibility of HIIT in inactive adults.

Overall, this novel study has profound public health applications as it will assess fitness and health related changes to a small dose of PA in the largest sample to date. If substantial changes in CRF are shown, these data have the potential to modify public health guidelines for implementing PA in inactive adults.

Conditions

Inactivity, Physical

Overweight (BMI > 25)

Healthy Participants

Study ID

NCT07328568

Start date

Nov 5, 2025

Status verified date

Aug, 2026

Completion date

Sep 1, 2028

Anticipated

Primary completion date

Jun 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Healthy
  • BMI < 35 kg/m2
  • younger than 56 yr old
  • no joint issues

Exclusion Criteria:

  • Those adults who are currently active and not weight stable
  • Adults with BMI > 35 kg/m2
  • Use of medications which may alter study outcomes

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Intervention group

This group will perform long term REHIT.

placebo comparator: Non exercising control group

This group will not complete REHIT, and will be given the option to complete the training once post testing is performed.

Interventions

High intensity interval training

Participants will complete 24 sessions of REHIT and their responses will be compared to a non exercising control group.

Primary outcome measure

  • Cardiorespiratory fitness [ Time Frame: CRF will be assessed at baseline 48 - 72 hours before the start of training, and at 6 and 12 weeks of training, which represent halfway and end of training. The assessments will be performed at least 24 hours after sessions of exercise training. ]

Central Contacts and Locations

Central contacts

Todd A Astorino, Ph.D

760750-7351astorino@csusm.edu

Locations

California State University--San Marcos Human Performance Laboratory

Recruiting

San Marcos, California, United States, 92096

Contacts

Todd A Astorino, Ph.D

astorino@csusm.edu

Principal Investigator:

Todd Anthony Astorino, Ph.D

More Information

Sponsor

California State University, San Marcos

Last update posted

Aug 24, 2026

Last verified

Aug, 2026

Keywords

  • high intensity interval training
  • maximal oxygen uptake
  • fat metabolism
  • affective valence
  • body composition
  • exercise adherence

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-11. This information was provided to ClinicalTrials.gov by California State University, San Marcos on 2026-08-24. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.